Optimizing T Cell Expansion in Ambr^® 15 Cell Culture Using DoE and Process Transfer to Ambr^® 250 Modular

For many therapeutic cellular products, the development of a scalable cell expansion process optimized for quality and costs is a crucial step in the manufacturing process. Ambr^® 15 provides the capability to screen different types of media, and optimize process parameters with these cell types under stirred conditions at the small scale and with high throughput operation offering many advantages over static culture. The findings at this scale can be transferred to benchtop or larger scale bioreactor processes.