Resource Overview
Loss on Drying is a back-weighing application used to determine the amount of volatile matter present in tablets, capsules or bulky material. Samples are weighed before and after treatment and the difference in weight is measured.
According to USP the “dry to constant weight,” or according to European Pharmacopoeia (PhEur) the “dried to constant mass” or “ignited to constant mass” weight value of pharmaceutical products is to be measured. The USP defines that two consecutive weighings must not differ by more than 0.50 mg per g of sample, whereas the PhEur specifies that two consecutive weighings must not differ by more than 0.5 mg in total to consider the sample as dried to constant weight or mass.
In the Cubis® II application, the administrator selects between the test procedure according to USP or PhEur, and the sample type - tablet or capsule. Due to the different definition of allowed weight difference, the selection determines the mode, or how the software application considers samples to have passed or failed the test.
Key takeaways:
- Loss on Drying is a back-weighing application on Cubis® II balances that streamlines the back-weighing process
- It automatically evaluates results according to USP or PhEur standards
- The Loss on Drying application provides comprehensive reports and direct user feedback on out-of-limit results
Resource details:
- Document type: Application Highlight
- Page count: 5
- Read time: 5 minutes
