White Paper: Minimum Sample Weights According to Various Pharmacopoeias, OIML R76 and EURAMET cg-18

Authors: Dr Julian Haller, Dr. Ellen Hage, Axel Taube | Last updated: September 2026

Resource overview

What is the minimum weight a sample must have to obtain a reliable weighing result? 

The smaller the weight of the sample, the larger the relative measurement uncertainty that the weighing is subject to. There are various concepts for specifying corresponding minimum sample weights so as not to exceed a specified relative measurement uncertainty.

The most well-known concepts are those of various pharmacopoeias (particularly the United States Pharmacopeia, as well as the European, Japanese, and Chinese Pharmacopoeias), OIML R76, and the EURAMET Calibration Guide No. 18. This White Paper explains and compares the different minimum sample weight concepts. Additionally, typical minimum weighing values for various Sartorius balance models are listed.

 


Key takeaways:

  1. Learn why minimum sample weight is essential to limit relative measurement uncertainty
  2. Learn how minimum sample weight is calculated according to different Pharmacopeias, OIML R76, and EURAMET cg 18
  3. Learn about the key points of the minimum sample weight concept
     

Resource details:

  • Document type: White paper
  • Page count: 10
  • Read time: 10 minutes

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