Protein Crystallography in Alzheimer’s Research The Influence of Ultrapure Water Quality
Authors: Oliver Kupski and Elmar Herbig
Alzheimer's disease is a progressive, incurable neurodegenerative disorder that primarily affects middle-aged and elderly people. Approximately 1.2 million people suffer from this disease in Germany, which is associated with loss of memory, language and cognitive function, as well as personality changes and severe mood swings.
Overview
This scientific article aims to provide a better understanding of the molecular mechanisms involved in the onset of Alzheimer's disease and to develop the basis for new types of treatment. It focuses on the enzyme glutaminyl cyclase (hQC) and its role in the formation of amyloid beta-peptides, which are central to Alzheimer's disease pathology.
Learn about the influence of ultrapure water on protein crystallography, particularly for Alzheimer’s research, and how water purity supports the production of reproducible and well-defined protein crystals and structural models.
Page count: 7
Read time: 10 minutes
Last updated: November 2023
Key Takeaways
- The integrity of protein crystals is significantly influenced by the quality of water used, underscoring the necessity of ultrapure water for reliable studies
- Protein crystallography allows for the atomic-level analysis of hQC's structure, offering insights into its role in Alzheimer's disease
- Using ultrapure water is key to achieving consistent and dependable results in protein crystallography
- Detailed structural models of hQC can inform the development of new therapeutic strategies to combat Alzheimer's disease
This Resource is Designed for:
- Neuroscientists
- Biochemists
- Pharmacologists
- Protein Crystallographers
- Lab Managers
- Lab Technicians
- Scientists Researching on Alzheimer's Disease
Applications Supported:
- Protein Crystallography
- Alzheimer’s Disease
- Chronic Neurodegenerative Disease
- ASTM Type I Water
- Laboratory Water
- Ultrapure Water
- Arium® Pro VF Ultrapure Water System
- Human Enzyme Glutaminyl Cyclase (hQC)
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