Minimizing LCMS Artifacts Using Arium® Ultrapure Water Systems
Authors: Charles Prochaska, Dr. Kunal Kureja, Lindsay Morrison & Dr. Izabella Surowiec
Overview
Water quality is critical in liquid chromatography coupled with mass spectrometry (LCMS) applications. Ultrapure water that meets ASTM Type I specifications is essential for mobile phase preparation, sample dilution, reagent preparation and instrument cleaning.
Water impurities such as particulates, bacteria and ions can affect chromatographic performance, resulting in poor data quality, overlapping peaks, ghost peaks and column damage. The freshly produced ultrapure water from Arium® Mini UV systems can help you overcome water contamination and unlock the full potential of LCMS analysis.
Find out how Arium® Mini can help minimize LCMS artifacts.
Document type: Application Note
Last updated: January 2024
Read time: 15 minutes
Key Takeaways
- Importance of high-quality ultrapure water in LCMS applications
- Impact of water impurities (organic compounds, organic and inorganic contaminants)
- Benefits of the Arium® Mini Ultrapure Water System
- How in-house produced Arium® Type I water is financially advantageous over bottled water
This Resource is Designed for:
- Lab Technicians
- Lab Managers
- Post Doc Students
- Analytical Scientists
- Pharmaceutical Researchers
- Biologists and Life Scientists
- Clinical Laboratories
- Environmental Scientists
- Forensic Experts
- Food and Beverage Industry
- Chemical Industry
- Academic Researchers
- Regulatory Authorities
- Quality Control or Validation Lab
Applications Supported:
- Liquid Chromatography Mass Spectrometry (LCMS)
- Ultra-Performance Liquid Chromatograph (UPLC)
- Chinese Hamster Ovary (CHO) Cell
- Total Organic Carbon (TOC)
- Monoclonal Antibody
- Ultrapure Water
- ASTM Type I Water
- Arium® Mini UV
- Waters BioAccord LCMS
- Sartorius Ambr® 15
- Waters Connect™
