Handbook for Scientists: AAV Downstream Processing and Analytics

Last updated: February 2026

Resource Overview

Adeno-associated viruses (AAVs) are leading vectors for gene therapy due to their non-pathogenic nature, low immunogenicity, and growing track record in approved treatments. Successful AAV therapies require robust, scalable upstream and downstream processes that deliver high titers while preserving genome integrity, purity, and biological activity. This eBook outlines end-to-end solutions for AAV USP, DSP and Analytics. Together, these lab-scale and bioprocess solutions support efficient development, optimization, and large-scale manufacturing of AAV-based therapies.

 

Resource details

  • Document type: eBook
  • Page count: 106

 

Key takeaways

  1. Focus on downstream processing for AAV gene therapy.
  2. Lab-scale DSP workflows for development and optimization.
  3. Scalable, robust DSP solutions for production scale.
  4. Analytics and QC for titer, integrity, potency, and safety.

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This resource is designed for:

  • Process development scientists and engineers working on AAV platforms
  • Manufacturing and MSAT teams scaling AAV processes to GMP production
  • Analytical development and QC scientists supporting AAV characterization

Applications supported:

  • Clarification
  • TFF
  • Chromatography
  • Sterile Filtration
  • Sterility Testing
  • Capsid titer Determination (Octet)
  • Transducing Titer Determination (Incucyte / iQue Screener)