Combining AI-Powered mRNA Design With Non-Viral Delivery to Achieve Organ-Specific Targeting
On-Demand Webinar
Watch this webinar to explore how cationic lipid-based transfection coupled with AI-powered mRNA design can enhance expression and tissue specificity for in vivo RNA delivery. Effective tissue-specific delivery remains a key challenge in the development of mRNA therapeutics. Achieving organ and tissue-specific delivery remains a perennial challenge for the mRNA-LNP therapeutic space, as ionizable LNPs predominantly accumulate in the liver, restricting their use for therapeutic development in other organs. In contrast, a transfection reagent based around LipidBrick®IM21.7c cationic lipid, offers an effective, simple and cost-efficient alternative with a broader biodistribution profile, enabling multi-organ mRNA delivery beyond the liver. Officinae Bio joins us to present case study data covering strategies for improved biodistribution using our transfection reagent, along with key considerations in the mRNA design space such as capping analogs and chemical modifications.
What You Will Learn:
- Key benefits and drawbacks of LNPs versus cationic lipid-based transfection reagents for in vivo mRNA delivery
- Exploring mRNA design spaces across UTRs, capping analogs, and chemical modifications that can improve targeted mRNA expression
- Improving biodistribution beyond the liver while also simplifying processes and reducing costs