AAV6 Capsid Optimization with CIM SO3 Plates & Mass Photometry

Webinar | AAV6 Capsid Optimization with CIM SO3 Plates & Mass Photometry

AAV6 Capsid Optimization with CIM SO3 Plates & Mass Photometry

On-Demand Webinar

This webinar will highlight new research focused on optimizing AAV6 upstream production – an essential step in improving the safety and affordability of gene therapies. Using a design of experiment (DoE) approach, the Sartorius BIA Separations team systematically identified the optimal conditions to achieve a high full capsid ratio. Further optimization was conducted with the Ambr15 system, while CIM SO3 monolithic plates enabled efficient high-throughput purification of upstream samples. Mass photometry was used to accurately assess capsid species ratios, supporting more precise and scalable production.

What You Will Learn:

The use of CIM SO3 plates for high-throughput purification of AAV upstream samples, ensuring the necessary purity for analytics
Techniques to determine optimal production conditions for achieving the highest empty/full capsid ratio using mass photometry
Strategies to accelerate your production process with Ambr15

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AAV6 Capsid Optimization with CIM SO3 Plates & Mass Photometry

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