Dr. Linas Urbonas, Polytec
How long can the optical fibers be, that are connecting sensors and spectrometer?
Optical fibers can be up to 100m long.
Is this system suitable for fast reaction monitoring? What is the highest measurement rate possible?
Yes, definitely it is suitable. The shortest measurement time depends on the sample properties and the probe used, but in some cases, the measurement rates can reach 100 Hz.
How often is it required to maintain/calibrate a spectrometer system?
The NIRS system is robust, specially developed for industrial applications, without any movable optical parts. So theoretically no maintenance/calibration is required. However, we do suggest performing preventive maintenance every couple of years.
How does the SIMCA® software cope with inter-instrument differences?
NIRS instruments are manufactured and calibrated in such a way, that calibrations can be transferred from one instrument to another. In some cases, for very sensitive parameters, bias and slope adjustment may be required, which is done by measuring a few samples with the new instrument.
Do you store all spectra, when you measure in the ms range, or do you only forward and store the prediction value?
All the spectra and results are stored in the PC (Server PC) and could be accessed/downloaded at any time. The prediction values are automatically forwarded through PLC for process control.
How does the SIMCA® software cope with NIR inter-instrument differences?
Dr. Fabien Chauchard, INDATECH
What happens if one vial is detected as out of spec, is it automatically removed and stored for additional analysis?
Yes, the vial is automatically rejected by the GEA system. It can be analyzed later on if necessary.
Has the glass vial (thickness, impurities, shape) had an impact on the NIR predictions?
No, the optical setup makes the system quite robust to wall thickness or impurities. However brown glass vial need a specific model
Do you think OPC UA is interesting to be used only at the production scale?
OPC UA can also be used in the laboratory in order to automate easier the measurement and generate an automatic saving of data in the global database.
What is the advantage of importing a SIMCA® USP model versus having an acquisition software applying directly the chemometrics?
USP file embedded preprocessing, model type, and database. For this reason, it provides better traceability and decreases the risk in putting the model inline
Regarding the UV ASURYAN system, Is there another advantage than just optimizing Signal to noise ratio when using different probe pathlength?
Having different pathlength is also interesting for improving calibration and model transfer. Different pathlength can provide a direct measurement of absorption without the effect of pathlength and thus a direct relation with concentration
Is multi-probe UV spectroscopy capable to quantify multiple proteins using MVDA in one shot?
Yes, however, some proteins may overlap a lot and in that case, preprocessing will be critical to separate the information.
Can this technology be used for in-line measurement of isotope enrichment or separation (medical isotopes)?
We haven't tried that. But it can be tested.