Webinar Advancing PAT Analytics with SIMCA® for LC-MS Data Processing

Advancing PAT Analytics with SIMCA^® for LC-MS Data Processing

This webinar covers SIMCA's role in processing LC-MS data acquired through bioprocess walk-up solutions from Waters. The webinar will explore how to acquire time course data from key applications in bioreactor monitoring (e.g., ProA analysis, spent media, quality attribute assays). We will discuss and highlight workflows for combining those streams of data in SIMCA^®, along with standard analyzer/sensor readings and DOE experimental variables. The session will demonstrate how to use SIMCA to analyze process parameters and quality attributes across a multi-vessel, multi-timepoint study.

A 14-day case study using an 8-way Ambr^® modular system will be presented. Experimental data from eight vessels run using a simple three-factor DOE setup was collected for multiple LC-UV and LC-MS based assays. The webinar will show how to integrate bioreactor variables, analyzer outputs, and LC-MS data into SIMCA^® for a comprehensive dataset. With SIMCA’s MVDA tools, we are able to visualize relationships and dependencies over time, across variables and analytic methods.

What You Will Learn:

Gain an understanding of bioprocessing and PAT analytics using Waters instrumentation
Learn how to process and analyze data using SIMCA^®
Discover how software can help streamline multiple data sources including LC-MS data for holistic process insights

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Presenter

This webinar is presented by Mark Wrona, consulting scientist at Waters. Mark has worked with liquid chromatography and mass spectrometry for over 20 years developing and supporting quantitative and qualitative workflows for the pharmaceutical industry. Mark started his career at Merck Research Laboratories in 2004, working as an analytical chemist in drug discovery before joining Waters in 2010. Most recently, Mark has been managing a small, talented, global team of chemists focused on developing, collaborating with thought leaders and testing solutions for bioprocess and PAT applications.