Evaluating how cationic lipid affects mRNA-LNP physical properties and biodistribution

Innovating Molecules for Drug Delivery

The journey of discovering and developing new medications is often lengthy and expensive. To streamline drug discovery, reduce time to market, and cut costs, Sartorius Corporate Research integrates novel chemistry concepts with machine learning, designing innovative molecules that enable non-viral or viral vector delivery. This approach is applied to the development of next-generation nanoparticles for targeted tissue delivery and the design of new polymers that enhance large-scale viral vector manufacturing.

Our Work

Lipid Nanoparticles

Lipid nanoparticles (LNPs) are nanoscale particles composed of lipids used to deliver therapeutic agents, such as RNA or DNA, into cells. They protect the genetic material and facilitate its entry into target cells, enhancing treatment efficacy. LNPs have unique propierties that make them useful in a variety of applications, such as medical imaging or drug delivery, and demonstrated its potential during the coronavirus pandemic.

Sartorius is advancing new concepts in supramolecular chemistry to develop libraries of active lipids. Our solutions are designed to accelerate formulations discovery process. Scientists can target specific tissues through optimization of the nanoparticles self-assembly.

Gene Therapy

Gene therapy is a technique that involves modifying or manipulating individual's genes to treat or prevent a disease. It aims to correct defective genes, introduce new genes, or alter gene expression to restore normal function or combat illness. Viral vectors like Adeno-associated Virus (AAV) or Lentivirus (LV) are known for their gene delivery capabilities, achieving short- and long-term transgene expression. However, challenges exist in large-scale production, purity, and shelf-life, involving plasmid development, viral production, and purification.

Sartorius offers innovative solutions to enhance the yield and quality of viral vectors, supporting advancements in gene therapy.