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Advancing AAV Manufacturing Through Innovative Process Development
The commercial viability of AAV therapies is limited by manufacturing challenges, including low yields, high variability, and scale-up constraints. This application note presents a systematic process development approach for AAV8 vector production, developed in collaboration with Matica Biotechnology. The integrated workflow combines upstream optimization, downstream purification, and analytical characterization to establish robust operating parameters, improve product quality, and support scalable, reproducible manufacturing.
Key learning objectives:
- Discover how upstream parameters are optimized using high-throughput bioreactors
- Explore robust downstream strategies for clarification, TFF, and chromatography
- Learn how integrated workflows enable scalable AAV8 manufacturing
