Scaling AAV Production: Transitioning From 250mL to 200L

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Scaling AAV Production: Transitioning From 250mL to 200L

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Scaling AAV Production: Transitioning From 250mL to 200L

Ascend Advanced Therapies and Sartorius demonstrate seamless AAV production scale-up from 250 mL to 200 L using the EpyQ^®AAV Production System with HEK293 cells. Consistent productivity and critical quality attributes are maintained across Ambr^®250, Univessel^® SU, and Biostat STR^® bioreactors.

800-fold scale-up with robust AAV yields and quality
Stable mixing and kLa across bioreactor scales
High full capsid ratio and low process-related impurities

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Scaling AAV Production: Transitioning From 250mL to 200L

Scaling AAV Production: Transitioning From 250mL to 200L

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