Ultrapure Water for LCMS: What You Need to Know
Author: Tiffany Yesavage, Ph.D., Published by BioCompare
Liquid chromatography-mass spectrometry (LCMS) is a common analytical technique that combines high-resolution chromatographic separation with mass spectrometry for identification and quantification of various substances. LCMS requires ultrapure water not only for the mobile phase, but also for sample dilution, standards, blanks, sample preparation, rinsing, and instrument cleaning.
Overview
There are common contaminants that affect LCMS performance, such as organic compounds, bacteria, particulate matter, dissolved atmospheric gases, and inorganic ions. These contaminants can cause a variety of problems, including peak overlap, baseline instability, high background noise, ghost peaks, potential column damage, and lack of reproducible results.
Download the article to learn more about ultrapure water for LCMS and how ultrapure water systems can reduce contamination.
Read time: 8 minutes
Last updated: November 2023
Key Takeaways
- What is ASTM Type I water?
- What water contaminants should I be concerned about?
- How Arium® water systems can reduce contamination and provide ultrapure water
- Tips for avoiding contamination
This Resource is Designed for:
- Lab Technicians
- Analytical Chemists
- Quality Control Professionals
- Pharmaceutical Researchers
- Academic Researchers
- Food Scientists
- Forensic Scientists
Applications Supported:
- Liquid Chromatography Mass Spectrometry (LCMS)
- Total Organic Carbon (TOC)
- Water Impurities
- Ultrapure Water
- ASTM Type I Water
- Arium® Ultrapure Water Systems
- Arium® Mini Essential UV System
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