Scaling Process Intensification from Seed Train

On-Demand Webinar | Scaling Process Intensification from Seed Train to Production in Biomanufacturing

Process intensification strategies promise to reduce biomanufacturing costs and increase productivity. Strategies include intensifying the seed train—increasing inoculation density and thereby reducing the number of cell expansion steps—or intensifying the production stage bioreactor process itself. However, many promising strategies fail to translate during scale-up due to platform inconsistencies, oxygen transfer limitations, or poor system integration.

In this GEN webinar, experts from Sartorius will discuss how a modular, single-use portfolio enables process intensification from seed train to production. During the webinar, they will present high cell-density perfusion data in both rocking-motion and stirred-tank reactor (STR) platforms and introduce an intensified sparger for STRs that almost doubles oxygen transfer, delivering corresponding gains in peak cell density.

What You Will Learn:

Details of a scalable portfolio that leverages consistent vessel geometry and integrated cell retention devices.
How perfusion strategies and results translate from development to manufacturing.
Economic and environmental benefits of transitioning from classic to intensified process technologies.

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John Betts

Product Manager

John Betts is a product manager at Sartorius with a focus on benchtop bioreactor technologies. He has over 15 years’ experience in bioprocessing, product management, and technology innovation. He is particularly interested to learn from customers about the complex challenges they face when developing and manufacturing biologics, and to explore with them development or implementation of solutions to make these medicines better and more accessible.

John has worked at Sartorius for over 10 years in several roles, including previously leading concept development across the Ambr^®technology platform. He holds a doctorate in biochemical engineering from University College London, a mini-MBA from The London School of Economics, and a BSc in molecular biology from Durham University.

Paulo Santos Galrão

Product Specialist, Process Intensification

Paulo Santos Galrão is a product specialist for process intensification at Sartorius. He has eight years of experience in upstream bioprocessing and optimization of gene therapy production in perfusion‑intensified bioreactors. He helps biomanufacturers design, implement, and troubleshoot end‑to‑end intensified upstream strategies to address scale‑up, robustness, flexibility, and integration challenges.