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Benchmarking Chromatography for mRNA-LNPs: Monolith-Based Purification Strategies from Characterization to Scale-Up

On-Demand Webinar

As lipid nanoparticle (LNP)-based therapeutics diversify and regulatory expectations for complex nucleic acid products mature, analytical strategies must evolve. Modern LNP characterization now requires integrated workflows that can simultaneously assess particle size, quantify payload, and detect critical impurities.

Dr. Mojca Tajnik Sbaizero, a specialist with 10 years of experience in downstream processing for viral and non‑viral delivery, and  Tristan Kovačič, who leads formulation development for non‑viral nucleic acid delivery together, they will demonstrate how emerging chromatographic platforms enable multi‑parameter LNP characterization and support robust, scalable analytical strategies across diverse delivery systems. They will also show how these same approaches help generate functional, uniform LNP particles for final drug product development.

As LNP complexity increases, these experts will outline the growing need to separate distinct particle subpopulations and explain how advanced chromatographic separations enhance consistency, safety, and overall product understanding, ultimately strengthening progress in drug development.

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