Scalable Solutions for Optimizing Lentiviral Vector Production

On-Demand Webinar | Scalable Solutions for Optimizing Lentiviral Vector Production

Lentiviral vectors (LVs) are essential tools in cell and gene therapy, known for their ability to integrate therapeutic genes stably into the genome of target cells. This ensures long-term expression and effectiveness in treating genetic disorders. As the demand for LVs continues to grow, developing efficient production processes is critical for achieving high yields and increased quality.

In this webinar, we will showcase the optimization of a scalable LV production process using a high-throughput, automated microbioreactor system. The speakers will provide insights to aid in the optimization and scale up of LV production processes, ensuring a consistent supply of high-quality LVs for clinical applications. They will further highlight the impact of key parameters on LV production, including DNA, pH, dissolved oxygen, and stirring speed.

What You Will Learn:

How to optimize LV production using DoE in an automated small-scale bioreactor
Discover the benefits of switching to a next-generation LV transfection reagent
Explore the effects of key parameters on LV production

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Kathrin Teschner

Senior Scientist

Kathrin Teschner has been working for Sartorius since 2021 as part of the product development team, focused on process and media optimization for viral vector production. Before joining Sartorius, Kathrin earned her doctorate in molecular biotechnology at Bielefeld University. Kathrin started her career as a Post-Doctoral Research Associate working on the use of AAV in cancer gene therapy. As of 2024, she has been working as a Senior Scientist for Viral-Based Therapies with a focus on lentiviral vectors. 

Vera Orsteifen

Manager of Media and Process Development

Vera joined Sartorius Xell in 2021. Since September 2023, she has worked as the Manager of Media and Process Development at Sartorius Xell. Previously, Vera worked as a Manager of Media and Data Science.  

Vera holds a PhD in Industrial Biotechnology from the Center for Biotechnology (CeBiTec, Bielefeld University), and has a scientific background in molecular biotechnology, systems biology, bioinformatics, and cell culture technology. Before joining Sartorius Xell, she coordinated the German activities within the European Life Science Infrastructure for Biological Information and was also an active member of the CeBiTec Executive Board. 