Screening Sartopure^® filter trains for efficient LV clarification

Clarification must remove cells and debris from crude lentiviral vector harvests while preserving infectivity and protecting downstream purification steps.

This application note evaluates six Sartopure^® filter train configurations to determine how primary and secondary filter selection influences throughput, turbidity reduction, and infectious titer recovery.

Key learning outcomes:

1. Learn which primary filter delivered up to 1.8-fold higher load capacity
2. Understand how filter selection influenced turbidity reduction
3. See that LV infectivity remained comparable across all filter combinations