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Design of Experiments-Guided Optimization of Sartobind® Rapid A mAb Capture Achieves Resin-Like Buffer Efficiency
Membrane chromatography offers high productivity for mAb capture but typically requires higher buffer volumes than resin-based processes. In this application note, a DoE approach was applied to Sartobind® Rapid A to reduce wash buffer consumption to resin-comparable levels while maintaining host cell DNA and protein clearance. The optimized conditions were scalable and delivered higher productivity with lower cost of goods.
Key Takeaways:
- Learn how DoE optimization reduces buffer use in Protein A membrane chromatography
- Understand how Sartobind® Rapid A achieves resin-like efficiency with higher productivity
- See how optimized wash conditions scale linearly from nano to process scale
