Modeling freeze-thaw processes with the Celsius^® S³ benchtop system

Freezing and thawing can affect bulk drug substance stability, making representative scale-down studies important for process development. This application note demonstrates how the Celsius^® S³ benchtop system reproduced temperature profiles from production-scale Celsius^® FFT 75 L containers, supporting formulation development, stability assessment, and process selection.

Key Takeaways

1. Learn how production-scale freeze-thaw profiles were translated into lab-scale recipes

2. Compare critical freezing and thawing parameters between 100 mL and 75 L scales

3. Explore how matched freeze-thaw profiles could support formulation and stability studies