Enhancing Lentiviral Vector Purification: Scalable TFF With Hollow Fibers

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Enhancing Lentiviral Vector Purification: Scalable TFF With Hollow Fibers

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Enhancing Lentiviral Vector Purification: Scalable TFF With Hollow Fibers

Lentiviral vector (LV) production is challenging due to shear-sensitivity, particularly during tangential flow filtration (TFF) steps. Traditional purification methods are not scalable and often compromise viral integrity.

This application note presents a comprehensive analysis of Sartorius hollow fiber TFF technology for the ultrafiltration | diafiltration (UF | DF) of LVs for gene therapy applications.

Key Takeaways:

Learn how hollow fiber TFF supports scalable UF | DF of LVs.
Examine consistent flux and pressure profiles across module sizes.
Evaluate impurity clearance and infectivity data.

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Enhancing Lentiviral Vector Purification: Scalable TFF With Hollow Fibers

Enhancing Lentiviral Vector Purification: Scalable TFF With Hollow Fibers

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