Enhancing bioprocess scalability with the Univessel^® SU 10 L

Transferring intensified CHO cell processes from development to manufacturing requires consistent bioreactor performance, process control, and data across working volumes. 

This application note demonstrates a scalable N-1 perfusion process across the Ambr^® 250 High Throughput system, Univessel^® SU 10 L, and Biostat^® STR^® 50 L bioreactors, using aligned process parameters, online biomass monitoring, and harmonized data collection to support standardized process transfer.

What You Will Learn:

1. See how N-1 perfusion was implemented across 250 mL, 10 L, and 50 L scales

2. Compare high-density cell growth, viability, and metabolite control across scales 

3. Understand how shared vessel design and DO control support predictable scale-up