Thank you - Your Download is Available Below
Advancing Gene Therapy Recombumin® Human Albumin Poster
Gene and cell therapy using viral vectors - particularly adeno-associated viruses (AAVs) — is transforming the treatment landscape for a range of genetic and chronic conditions. However, a critical bottleneck remains: preserving AAV stability during storage and handling. AAVs are highly sensitive to temperature fluctuations and can degrade rapidly above -80°C, leading to loss of biological activity and compromised therapeutic efficacy.
We demonstrate that Recombumin®, a high-purity recombinant human albumin, significantly enhances the stability of AAVs across a wide range of storage conditions, ensuring superior preservation and reliability. As a multifunctional excipient, Recombumin® provides several key benefits:
- Prevents surface adsorption
- Minimizes particle aggregation
- Protects against mechanical shear stress
- Acts as a powerful antioxidant
Unlike serum-derived or other recombinant albumins, Recombumin® offers superior purity, high stability and a minimal aggregation profile. This ensures that there will be no confounding results from a degrading albumin. High stability albumin is a critical property, proven tomaintain consistent protection of AAV capsid integrity and concurrent functionality.
Furthermore, when formulated with specific anions, buffers, salts and excipients, Recombumin® provides enhanced viral stability. This leads to extended shelf life, more flexible storage conditions, and reduced product waste. Improved preservation of viral titers may also enable lower dosing requirements, ultimately decreasing manufacturing costs and increasing the accessibility of gene and cell therapies.
