Application Note: Filtration of Viscous Samples for Microbiological Quality Control
Authors: Dr. Nils Jäger, Anna-Lena Weißenborn, Juliane Großmann | Last updated: June, 2023
Overview
Microbial enumeration through membrane filtration is a crucial component of quality control in biotechnological, pharmaceutical and cosmetic applications. However, this process can pose challenges when dealing with viscous and oily substances such as creams, ointments, and solutions. In compliance with pharmacopoeial guidelines, such substances may be diluted with a suitable sterile diluent, such as isopropyl myristate (IPM), or the temperature of the sample may be raised to facilitate filtration. This study aimed to examine the impact of temperature and dilution on the filtration rate of viscous oils using Microsart® @filter units.
The results of this study provide valuable insights into the most effective methods for microbial enumeration of viscous substances.
- Document type: Application Note
- Page count: 3
- Read time: 5 minutes
Key Takeaways
- Sample dilution in isopropyl myristate (IPM).
- Benefits of diluting samples
- Chemical compatibility of the Microsart® @filter units to IPM
This Resource is Designed for:
- QC Microbiologist
- QC manager
- Microbiology Manager
Applications Supported:
- Microbial Enumeration
- Microbial Quality Control
- Filtration of Viscous Samples