Highest Manufacturing Quality Standards
Global Manufacturing Capabilities ISO Certified Following cGMP Guidelines
Sartorius manufacturing sites are currently engaged in the manufacture of over 1,500 products for pharmaceutical and biotechnology applications such as disease diagnosis, biomedical research, production of diagnostics and therapeutics, and quality control testing of pharmaceuticals and medical devices for the presence of bacterial contaminants. Manufacture of these products, specifically cell culture media, reagents, and buffers, follow the protocols and compliance specifications of the following industry regulations:
- 21CFR820
- ISO 9001: 2008 certified
Features & Benefits
Flexible and Scalable Solutions
Industry leader in batch size scalability | Liquid: 0.5 L to 10,000 L batch size; Powder: 7 kg to 7,000 kg batch size |
Global manufacturing sites | Assurance of supply |
Sartorius | Fit-for-purpose and ready to use solutions adding value to your processes |
Wide range of primary and secondary packaging | Answering your specific needs |
Sterility
Tests are performed on representative samples using the membrane filtration procedure in accordance with the US Pharmacopoeia or EP Pharmacopoeia. Culture media used are fluid thioglycollate medium (FTM) and trypticase soy broth (TSB). All tested media must pass growth promotion testing before use. The test samples are filtered and the filters are immersed in FTM and TSB. TSB cultures are incubated at 22.5°C +/- 2.5°C. FTM cultures are incubated at 32.5°C +/- 2.5°C. The cultures are incubated for 14 days, during which they are periodically examined and sterility results are recorded.
Cell Growth Promotion
Media and supplements are tested for their growth promoting properties using primary, diploid, and heteroploid cell lines unless other cells are appropriate based on the product use. Results are obtained using the Lowry protein method or manual cell count to assess cell replication. Visual screening of cultures is also done to ensure characteristic cell morphology and lack of toxicity. Additional testing for toxicity, function and/or activity may also be conducted if one or more is required in the product release specifications.
Moisture Content
This is a powder specific test. We are committed to offering the same high quality powdered media as you have come to expect with our liquid media. We utilize a unique micronization manufacturing process, which produces powder in a controlled environment, guaranteeing maximum stability and minimum degradation due to chemical oxidation.
Cell Growth Promotion
Media and supplements are tested for their growth promoting properties using primary, diploid, and heteroploid cell lines unless other cells are appropriate based on the product use. Results are obtained using the Lowry protein method or manual cell count to assess cell replication. Visual screening of cultures is also done to ensure characteristic cell morphology and lack of toxicity. Additional testing for toxicity, function and/or activity may also be conducted if one or more is required in the product release specifications.
Endotoxin
Products are tested for endotoxin content using the Kinetic-QCL™ Assay. Test dilutions used are screened for inhibition and enhancement in the Kinetic-QCL™ Assay. Endotoxin levels for these products are available on Certificates of Analysis.
Shelf Life
Samples from each lot of standard product are retained and stored at label temperature in the event follow-up testing is required. Subsequent testing may be in response to your inquiry or for shelf life studies. Shelf life data is not included but is available for some products and upon request. Shelf life is generally between 6 and 24 months for liquid products and 24 months for powder products.
Release Testing & Documentation
Quality Control from Start to Finish for Each Product
Written procedures in accordance with current Good Manufacturing Practices (cGMPs) to verify the conformity of material to established specification throughout the manufacturing process, inspections and testings occur during the following four stages: Raw material receipt | In-process manufacturing, labeling and packaging | Finished product | Post-manufacture for shelf life studies.
Liquids | Powders | |
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Testing Options | ||
Sterility | Standard | N/A |
pH | Standard | N/A |
Osmolarity | Standard | Standard |
Endotoxin | Standard | N/A |
Cell Growth Promotion | Standard on CHO medias | N/A |
Mycoplasma | On Request | N/A |
Moisture | N/A | Standard |
Bioburden | N/A | Standard |
Shelf Life | On Request | On Request |
Documentation | ||
CofA and raw material CoA | Standard | Standard |
Quality Attributes Based on Application
Documented & Defined Protocols for Each Product
Attributes | Product for resarch | Catalogue products and custom | Protein │ Vaccine production media for cGMP production | |
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Product use | For research use only | For upstream │ downstream biopharma process development | For upstream │ downstream Biopharma clinical phase 3 or commercial production | |
Quality Assurance | QA System | ISO 9001 | ISO 9001 | ISO 9001 and cGMP 21CFR821 |
Quality Control | Product Approval and Release | No QA inspection of documents | All products are released following an approved │ controlled an inspection of all quality documents harmonized between both sites | All products are released following an approved │ controlled QA inspection of all quality documents harmonized between both sites |
Product Storage amd Shipment | Shipment conditions | Theoretical shipment conditions | Harmonized shipping condition between sites supported by validation data | Harmonized shipping condition between sites supported by ASTM validation data |
Handling of customer demands | Confidentiality | N.A. | Confidential information shared under CDA | Confidential information shared under CDA |
Liquids
With a comprehensive range of bottles and bags we can offer standard off-the-shelf or customized containment from 0.5 liters up to 1,000 liters.
Powders
We offer a wide range of powder containers from 125 g bottles up to several 100 kg. We also provide ready-to-use solutions such as pre-weighted powder in bags, media kits, etc.
Shipping Solutions for Media & Buffers
Liquid Form
0,5 to 1L | 1 to 2,5L | 2 to 20L | 50L | 100L | 200L | 500L | 1000L | |
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Flexsafe® 2D Bag |
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Drum |
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Flexsafe® 3D Bag in Container |
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Stainless Steel Palletank |
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Plastic Palletank |
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Powder Form
10g to 5kg | 20kg | ||
Bucket |
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Drum |
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