mAbs | Downstream Process

Achieve High Recovery and Purity with a Simplified Downstream Process

Implement Unique Technologies for Your Bioprocess Platform

Our Process Development Team and Applications Specialists will show you all the options available for your Downstream mAb Process. The perfect mAb platform is flexible and can be quickly adapted to each new operating conditions. It can be scaled up from the purification of mg to kg of proteins, and easily transferred to various manufacturing plants. From primary recovery to polishing, including bioburden reduction, virus clearance strategy and buffer management; we offer cost-effective and robust single-use technologies as well as innovative solutions for an effective handling of your purified drug substance.

Downstream Process at a Glance

Step 1: Buffer Prep

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Step 2: Virus Inactivation

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Step 3: Polishing

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Step 4: Virus Filtration

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Step 5: Concentration | Buffer Exchange

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Step 6: Bulk Drug Substance Filtration

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Step 7: Freeze Thaw

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Choose the Most Effective Virus Clearance Strategy for Your Process

Highest Virus Safety for your Patients

Virus inactivation with FlexAct® VI, Sartobind® membrane chromatography and Virosart® filtration represent today’s spearheading technologies for quantitative virus and contaminant clearance. Together they form a unique orthogonal platform for state-of-the-art polishing of biopharmaceuticals, scalable from benchtop to production scale. Our hollow fibre virus filter membrane offers the highest degree of safety and virus removal combined with very high flow rates.

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Efficient and Robust Contaminant Removal

Sartobind membrane adsorbers enable efficient and ultra-rapid purification, greatly reducing process time and buffer consumption.

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Reduce Your Downstream Footprint and Lower Your Capital Investment

The FlexAct® central operating unit is interchangeable throughout multiple process steps - from buffer preparation to virus removal.

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Explore the Sartorius Platforms for Biomanufacturing

Vaccine Manufacturing, Process Development and Production

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Bioconjugation

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Regenerative Medicine

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Explore the Sartorius Platforms for Biomanufacturing

Vaccine Manufacturing, Process Development and Production

Learn More

Regenerative Medicine

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Bioconjugation

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