The vacuum manifolds are designed for the operation of Sartobind® 96-well plates consisting of 12 individual 8-strips. The 96-well plates contain Sartobind® membrane adsorbers and are screening tools for chromatography conditions, e.g. within Design of Experiments (DoE) studies. The manifolds are easy to use with quick release fittings and can be run without initial set up time. They can be easily configured for both flow-to-waste and collection of fractions.