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Virosart® HF

New high speed virus filtration.

The high flux PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications.

   

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Products (12)

Virosart® HF lab module 1.7 cm² - IT tested
Filtration Area
1.7 cm²
Integrity Tested
Yes
Virosart® HF lab module 1.7 cm²
Virosart® HF lab module 1.7 cm²
Item no.: 3VI--28-TCGML--V
Filtration Area
1.7 cm²
Integrity Tested
No
Virosart®HF Process Module 2.4 m² - non-sterile delivery
Filtration Area
2.4 m²
Integrity Tested
Yes
Virosart®HF Process Module 0.8 m² - non-sterile delivery
Filtration Area
0.8 m²
Integrity Tested
Yes
Virosart®HF 200 cm² - non-sterile delivery
Filtration Area
200 cm²
Integrity Tested
Yes

Application:

  • Virus clearance: Virosart® HF targets the removal of both small non-enveloped viruses (20 nm) e.g. PPV, MVM and larger enveloped viruses (> 50 nm) e.g. MuLV from biopharmaceutical feed streams.
  • Target molecule: The main application for Virosart® HF filters is the virus filtration of monoclonal antibodies (mAbs), antibody fragments (Fab) or small recombinant proteins (< 150 kD).
  • Positioning: Virosart® HF is used towards the end of the purification process of biopharmaceutical products for the virus filtration. At this stage, the purity of the biopharmaceutical product is at its highest and so fouling of the filter by contaminants (DNA, CHOP, aggregates & lipoproteins) will be low.

Product Benefits:

  • Robust virus clearance: Virosart® HF retains ≥ 4 LRV of small non-enveloped viruses (e.g. PPV, MVM) and ≥ 6 LRV of large enveloped viruses (e.g. MuLV). This filter offers highest virus safety over the entire flow decay profile independently of operating pressure.
  • Short processing times: Based on a unique modified PES membrane, Virosart® HF provides highest flow rates and excellent capacity.
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up and flushing volumes with low footprint requirements.
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® HF are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual filter is tested for integrity and for water flux during manufacturing
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins

Application Note

Application Guide - Virosart® HF: High Speed Virus Filtration for mAbs and Recombinant Proteins
en 1.8 MB
Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 1.5 MB
Impact of Pressure Release and Multiple Pressure Fluctuations on Virus Retention Performance of Virosart® HF Virus Retentive Filters
en 1.4 MB

Datasheet

Virus Filter Transfer Units (Gamma)
en 691.8 kB
Virosart® HF - High speed virus filtration for mAbs and recombinant proteins
en 1.2 MB

Flyer

Virosart® Virus Filters - Reliable Retention Under All Circumstances
en 2.8 MB

Poster

Case Study: Virus Filters Enabling Reliable Process Development in Antibody Processes
en 257.5 kB
Concept of a Fully Single-Use Virus Filtration
en 1.0 MB
Case Study: Increasing Virus Filter Throughput by Process Optimization Studies
en 894.1 kB

User Manual

Virosart® HF Labor Modul
en 194.4 kB
Instructions for Use Virosart® HF 3VI--28-… Process Modules
en 589.6 kB
Instructions for Use Virosart® HF 3VI--28-… Mid-Scale Modules
en 399.7 kB
Instructions for Use Virosart® HF 3VI--28-… Process Modules
en 583.7 kB
Sartocheck® 5 Plus Filter Tester
Sartocheck® 5 Plus Filter Tester
Item no.: 26787---FT---P

The Sartocheck® 5 Plus Filter Tester is an automatic filter integrity tester with automated Quality Risk Management (QRM) designed to cover the complete range of integrity testing from small syringe filters up to large multi-round housings and tangential flow cassettes.

Virosart® Max Capsule Height 4
Virosart® Max Capsule Height 4
Item no.: 54A1358N4--FF--B

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max Midicap® Height 9
Virosart® Max Midicap® Height 9
Item no.: 54A5358N9--FF--V

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max 10" T-Style Maxicaps®

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max 30" T-Style Maxicaps®

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max Minisart
Virosart® Max Minisart
Item no.: 54AMI----------B

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max Sartolab
Virosart® Max Sartolab
Item no.: 54ASA----------V

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Midisart® 2000
Midisart® 2000
Item no.: 17805--------TCN

Midisart® filters are available with PTFE (autoclavable) or PES (gamma-irradiatable | autoclavable) membrane. Ready-to-use, 100 % integrity tested and fully validated.

Virosart® HC Capsule Height 4
Virosart® HC Capsule Height 4
Item no.: 5391328V4--FF--B

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC Midicap® Height 9
Virosart® HC Midicap® Height 9
Item no.: 5395328V9--FF--V

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC 10" T-Style Maxicaps®

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC 30" T-Style Maxicaps®

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC Minisart
Virosart® HC Minisart
Item no.: 539VM----------B

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® CPV Capsule Height 4, Sanitary

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV Midicap® Height 9
Virosart® CPV Midicap® Height 9
Item no.: 5455328V9--FF--V

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV 10" Maxicaps®
Virosart® CPV 10" Maxicaps®
Item no.: 5457328V1--SS

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV 30" Maxicaps®
Virosart® CPV 30" Maxicaps®
Item no.: 5457328V3--SS

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV Minisart
Virosart® CPV Minisart
Item no.: 545VM----------B

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

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