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Virosart® HF

New high speed virus filtration.

The high flux PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications.

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Products (12)

Virosart® HF Lab Module 1.7 cm², Integrity Tested
Filtration Area
1.7 cm²
Integrity Tested
Yes
Virosart® HF Lab Module 1.7 cm²
Virosart® HF Lab Module 1.7 cm²
Item no.:   3VI--28-TCGML--V
Filtration Area
1.7 cm²
Integrity Tested
No
Virosart® HF Process Module 0.8 m², Non-Sterile
Filtration Area
0.8 m²
Integrity Tested
Yes
Virosart® HF Mid-Scale Module 200 cm², Non-Sterile
Filtration Area
200 cm²
Integrity Tested
Yes
Virosart® HF Mid-Scale Module 0.2 m², Gamma irradiated
Filtration Area
0.2 m²
Integrity Tested
Yes

Application:

  • Virus clearance: Virosart® HF targets the removal of both small non-enveloped viruses (20 nm) e.g. PPV, MVM and larger enveloped viruses (> 50 nm) e.g. MuLV from biopharmaceutical feed streams.
  • Target molecule: The main application for Virosart® HF filters is the virus filtration of monoclonal antibodies (mAbs), antibody fragments (Fab) or small recombinant proteins (< 150 kD).
  • Positioning: Virosart® HF is used towards the end of the purification process of biopharmaceutical products for the virus filtration. At this stage, the purity of the biopharmaceutical product is at its highest and so fouling of the filter by contaminants (DNA, CHOP, aggregates & lipoproteins) will be low.

Product Benefits:

  • Robust virus clearance: Virosart® HF retains ≥ 4 LRV of small non-enveloped viruses (e.g. PPV, MVM) and ≥ 6 LRV of large enveloped viruses (e.g. MuLV). This filter offers highest virus safety over the entire flow decay profile independently of operating pressure.
  • Short processing times: Based on a unique modified PES membrane, Virosart® HF provides highest flow rates and excellent capacity.
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up and flushing volumes with low footprint requirements.
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® HF are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual filter is tested for integrity and for water flux during manufacturing
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins

Application Note

Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 1.5 MB
Impact of Pressure Release and Multiple Pressure Fluctuations on Virus Retention Performance of Virosart® HF Virus Retentive Filters
en 1.1 MB
Appl-Guide_Virus-Filtration-Virosart-HF-e.pdf
en 1.8 MB

Datasheet

Datasheet Virosart HF
en 1.4 MB
Virus Filter Transfer Units (Gamma)
en 548.5 kB

Flyer

Virosart® — Highest virus safety for your patient — Next generation virus clearance concepts
en 886.6 kB

Poster

Case Study: Robustness Study for Virus Filtration
en 194.2 kB
Case Study: Increasing Virus Filter Throughput by Process Optimization Studies
en 301.3 kB
Poster_Case-Study_Virus-Filter_Throughput_BK_A2-e.pdf
en 263.7 kB
Concept of a Fully Single-Use Virus Filtration
en 844.5 kB

User Manual

Virosart® HF Labor Modul
en 194.4 kB
Virosart® HF 3VI--28-… Process Modules
en 171.4 kB
Manual Virosart® HF Mid-Scale Modules
en 207.7 kB
Virosart® HC Capsule height 4
Virosart® HC Capsule height 4
Item no.:   5391328V4--FF--B

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC MidiCap® height 9
Virosart® HC MidiCap® height 9
Item no.:   5395328V9--FF--V

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC 10" T-StyleMaxiCap®
Virosart® HC 10" T-StyleMaxiCap®
Item no.:   5398328V1--SS

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC 30" T-StyleMaxiCap®
Virosart® HC 30" T-StyleMaxiCap®
Item no.:   5398328V3--SS

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® HC Minisart
Virosart® HC Minisart
Item no.:   539VM----------B

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

Virosart® CPV Capsule height 4
Virosart® CPV Capsule height 4
Item no.:   5451328V4--FF--B

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV MidiCap height 9
Virosart® CPV MidiCap height 9
Item no.:   5455328V9--FF--V

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV 20" MaxiCaps® - New Design

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV 30" MaxiCaps® - New Design

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV Minisart
Virosart® CPV Minisart
Item no.:   545VM----------B

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Virosart® CPV Minisart IT tested
Virosart® CPV Minisart IT tested
Item no.:   545VM--------ITB

The PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications. Virosart® CPV is the optimal virus filter for monoclonal antibodies or small recombinant proteins.

Sartocheck® 4 Plus Filter Tester v 3.2

Fully automatic filter integrity testing device. In full compliance with 21 CFR Part 11 and GAMP5. A large accessory package makes Sartocheck 4 plus flexible, powerful and creates safe solutions for almost all customer needs.

Virosart® Max Capsule height 4
Virosart® Max Capsule height 4
Item no.:   54A1358N4--FF--B

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max MidiCap® height 9
Virosart® Max MidiCap® height 9
Item no.:   54A5358N9--FF--V

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max 10" T-Style MaxiCap®
Virosart® Max 10" T-Style MaxiCap®
Item no.:   54A8358N1--SS

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max 30" T-Style MaxiCap®
Virosart® Max 30" T-Style MaxiCap®
Item no.:   54A8358N3--SS

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max Minisart
Virosart® Max Minisart
Item no.:   54AMI----------B

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Virosart® Max Sartolab
Virosart® Max Sartolab
Item no.:   54ASA----------V

Maximize your virus filter performance with adsorptive pre-filtration. Virosart® Max is a specifically optimized virus pre-filter significantly increasing downstream virus filter performance.

Midisart® 2000
Midisart® 2000
Item no.:   17805--------TCN

Midisart® filters are available with PTFE (autoclavable) or PES (gamma-irradiatable | autoclavable) membrane. Ready-to-use, 100 % integrity tested and fully validated.

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