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Virosart® HC

The high capacity virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in blood & plasma applications.

   

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Products (10)

Virosart® HC Minisart IT tested
Virosart® HC Minisart IT tested
Item no.: 539VM--------ITA
Brand
Virosart® HC
Filtration Area
5 cm²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HC 20" Standard Filter Cartridge
Brand
Virosart® HC
Filtration Area
1.8 m²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HC Midicap® Height 9
Virosart® HC Midicap® Height 9
Item no.: 5395328V9--FF--V
Brand
Virosart® HC
Filtration Area
0.27 m²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HC Capsule Height 4
Virosart® HC Capsule Height 4
Item no.: 5391328V4--FF--B
Brand
Virosart® HC
Filtration Area
240 cm²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HC 10" Standard Filter Cartridge
Brand
Virosart® HC
Filtration Area
0.9 m²
Integrity Tested
Yes
Filter Type
Virus Filters

Application:

  • Virus clearance: Virosart® HC retains ≥ 4 LRV of small non-enveloped viruses (e.g. PPV, MVM) and ≥ 6 LRV of large enveloped viruses (e.g. MuLV).
  • Target molecule: The main applications for Virosart® HC for virus filtration are hydrophobic feed streams such as IVIG or any other plasma derivates as well as hydrophobic antibodies & recombinant proteins (< 150 kD).
  • Positioning: Virosart® HC is used towards the end of the purification process of biopharmaceutical products for the virus filtration. At this stage, the purity of the biopharmaceutical product is at its highest and so fouling of the filter by contaminants (DNA, CHOP, aggregates & lipoproteins) will be low.

Product Benefits:

  • Robust virus clearance: Virosart® HC retains ≥ 4 LRV of small non-enveloped viruses (e.g. PPV, MVM) and ≥ 6 LRV of large enveloped viruses (e.g. MuLV). This filter offers highest virus safety over the entire flow decay profile independently of operating pressure.
  • Smart process transfer: Flexibility is give by using either cartridges in existing stainless steel housings or disposable capsules.
  • Ease of use: Virosart® HC are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance:

  • Each individual filter is tested for integrity
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an
  • ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins
  • USP Plastic Class Test VI

Application Note

Autoclaving Virosart® CPV Minisart® Devices
en 630.7 kB

Datasheet

Virosart® HC - The high capacity virus filter for blood & plasma applications
en 1.7 MB

Flyer

Virosart® Virus Filters - Reliable Retention Under All Circumstances
en 2.8 MB

Poster

Robustness Study for Virus Retentive Filtration of Plasma Derivatives
en 419.8 kB
Adsorptive Pre-filtration to Increase Virus Filter Performance and Overall Process Robustness in Blood Derived Processes
en 2.2 MB

User Manual

Directions for Use - Virosart® HC Midicaps®
en 387.0 kB
Directions for Use - Virosart® HC Capsule
en 253.5 kB
Directions for Use - Virosart® HC Minisart®
en 320.4 kB
Virosart® HC 539 … Standard Filter Cartridges & T-Style Maxicaps®
en 393.1 kB

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