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Sartoclear® Depth Filter Cell Clarification and Contaminant Removal Technologies

Sartoclear® filters are cellulose-based depth filters developed for demanding clarification applications in the biotechnological and pharmaceutical industries.


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Various device formats are available to serve you from first the steps, throughout clinical phases and up to large scale manufacturing while always keeping the same filter material.


  • Mammalian cell culture harvests
  • Microbial lysates
  • Removal of precipitates from sera and plasma
  • Particle and colloid removal from process intermediates
  • Media Filtration



Application examples1


Very coarse primary grade on top of a coarse secondary filter for filtrations with high solid concentrations

Primary clarification of mammalian cell cultures, insect cell cultures, microbial fermentations, vaccines


Pure cellulose pre-filter combined with a coarse secondary filter

Primary clarification of mammalian cell cultures, insect cell cultures, microbial fermentations, vaccines


Coarse primary grade with a secondary fine filtration grade for lower to moderate solid concentrations

Post-perfusion bioreactors, vaccines


Fine filtration grade combined with a standard bioburden reduction grade for the removal of particles

Post centrifuge mammalian cell cultures, post primary depth filtration, process precipitates


Fine filtration grade followed by an very tight secondary filter for the removal of high concentrations of small particles

Post centrifuge microbial (e.g. E. coli) lysates, post primary depth filtration step, process precipitates

1 The listed examples are indicative and need to be confirmed by small scale tests


Available Formats for Scale-up

Sartoclear® Caps are easy to use screening devices that help you to find the best grade for your application. All packages contains 3 units of the same grade and come with plug-in Luer adapters for the easiest possible exchange of filters.

Sartoclear® Depth Filter Midscale Cassettes are developed for scale-up filtrations with volumes between five to 10 liters (depending on the cell density).

Sartoclear® Depth Filter Cassettes are single-use filtration devices especially designed for biopharmaceutical clarification applications. The unique modular devices provide linear scalability from small to large scale processes. Three different sizes allow for a seamless adaptation to different process fluid volumes.

Sartoclear® Depth Filter Lenticular Modules are stackable depth filters for use in stainless steel housings, which are often used in large scale manufacturing facilities for biologicals.


Sartoclear® Depth Filter Solutions
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