Hydrosart® high performance membrane is a stabilized cellulose based membrane that has been optimized for biopharmaceutical process applications. Hydrosart® is stable across a broad pH range, is extremely hydrophilic, making it non-protein binding, and virtually non-fouling. Membrane cleaning, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures and concentrations. These features make Hydrosart® an ideal membrane for biological applications.
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Hydrosart® ultrafiltration membranes are designed for use in the biotechnological and pharmaceutical industries. They can be used for the following applications: Oligonucleotide. proteins (albumin - even with 40% EtOH - . hemoglobin). coagulation factors (factor VIII. factor III). vaccines (tetanus. diphteria). monoclonal antibodies.
Hydrosart® shows minimal adsorption of proteins. viruses. etc. Membrane retention is unaffected by repeated use. The Hydrosart® ultrafiltration membrane can be re-used without any loss of integrity or performance. Hydrosart® ultrafiltration cassettes have been validated to withstand in-line steam sterilization without any loss or changes in membrane retention.
Depending on product viscosity and feed flow requirements, Hydrosart® Ultrafilter can be selected in a choice of two different screens.
Full flexibility and outstanding crossflow filtration performance combined
SARTOFLOW® Advanced is a modular benchtop crossflow system that can be configured to accept either Sartocon® Slice or full-sized Sartocon® cassettes. The system is optimized for ultrafiltration, microfiltration and diafiltration applications used in many downstream processes, such as purification of monoclonal antibodies, recombinant proteins or vaccines.
Sartocon® Slice Holder filter holder is designed for low to medium volume applications from 200 ml to 100 L and optimized for the use with up to five Sartocon® Slice Crossflow cassettes (0.1 – 0.5 m²). The filterholder can be sterilized by autoclaving or inline steaming.
Sartocon® Slice 200 stainless steel holder is optimized for the use with up to two Slice 200 Crossflow Cassettes (max. 400 cm²). It is designed for low volume applications from 20 ml to 5 L. The Slice 200 holder uses female stainless steel Luer lock connectors.
The SARTOFLOW® 20 stainless steel holder with hydraulic is designed for crossflow applications from 200 l to 2500 l volumes. The holder is optimized for use with 4 Sartocon® up to 20 Sartocube® production scale crossflow cassettes (max. 14 m2). Typical applications of the SARTOFLOW® 20 system includes concentration and diafiltration of proteins, vaccines, antibodies, oligo nucleotides, endotoxin removal etc., cell harvesting and clarification processes.
The SARTOFLOW® 10 stainless steel holder with hydraulic is designed for crossflow applications from 30 L to 1000 L volume. The holder is optimised for the use with up to ten Sartocon® or two Sartocube® production scale crossflow cassettes (max. 7 m²). Typical applications of the SARTOFLOW® 10 holder are concentration and diafiltration of proteins, vaccines, antibodies, oligo nucleotides, endotoxin removal etc. and cell harvesting and clarification processes.
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Find Out Why Hydrosart® Crossflow Membranes are so Productive
Crossflow Filtration (also known as Tangential Flow Filtration, or TFF) is a filtration method used under dynamic flow conditions. Product feed flows tangentially along the surface of the membrane where the product molecule is retained, while buffer and contaminants pass through the membrane. Sartorius Crossflow Ultrafilters contain Hydrosart TFF Membranes of various molecular weight cut-offs to manage volume reduction and buffer exchange in antibody, vaccine, and blood & plasma processes. Hydrosart is the preferred and best performing TFF membrane for biopharmaceutical manufacturing.