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MEP HyperCel Mixed-Mode Chromatography Resin

MEP HyperCel provides a unique separation mechanism and selectivity for protein separations, with ligand-based immunoglobulin selectivity optimal for monoclonal antibody capture and intermediate purification. The MEP ligand facilitates the binding of immunoglobulins as well as other target proteins at neutral pH under moderate salt concentrations.

   

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Products (9)

MEP HyperCel - 100 mL Mixed-Mode Chromatography Resin
Resin Format
Bulk resin
Pack Volume
100 mL
MEP HyperCel, RoboColumn 200 µL Mixed-Mode Chromatography Resin
Resin Format
Pre-packed column
Pack Volume
200 µL
MEP HyperCel, PRC Column 8 x 100, 5 mL Mixed-Mode Chromatography Resin
Resin Format
Pre-packed column
Pack Volume
5 mL
MEP HyperCel - 1 L Mixed-Mode Chromatography Resin
Resin Format
Bulk resin
Pack Volume
1 L
MEP HyperCel - 10 L Mixed-Mode Chromatography Resin
Resin Format
Bulk resin
Pack Volume
10 L
MEP HyperCel, PRC Column 5 x 50, 1 mL Mixed-Mode Chromatography Resin
Resin Format
Pre-packed column
Pack Volume
1 mL
MEP HyperCel, RoboColumn 600 µL Mixed-Mode Chromatography Resin
Resin Format
Pre-packed column
Pack Volume
600 µL
MEP HyperCel - 5 L Mixed-Mode Chromatography Resin
Resin Format
Bulk resin
Pack Volume
5 L
MEP HyperCel - 25 mL Mixed-Mode Chromatography Resin
Resin Format
Bulk resin
Pack Volume
25 mL
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MEP HyperCel is a flexible mixed-mode chromatography resin designed for capture and purification of antibodies and various recombinant proteins from laboratory to manufacturing scale.

MEP HyperCel resin offers a no salt/low salt alternative to conventional HIC and can simplify processes and improve economics by removing the need for salt addition and following UF/DF steps. The MEP ligand is immunoglobulin-selective. Thus, MEP Hypercel can be effectively used for IgG capture and for enhanced DNA, HCP and aggregate removal. Elution is under mild conditions.

Features and Benefits

- Unique separation mechanism and differentiated selectivity
- Direct protein capture from a variety of feedstocks
- No salt addition required for binding means a simpler process, lower costs and reduced waste
- Stable toward harsh cleaning with NaOH


Applications

- A no-salt/low-salt alternative to Hydrophobic Interaction Chromatography (HIC)
- Monoclonal and polyclonal IgG capture and intermediate purification (aggregate, DNA and HCP removal)
- Direct capture of recombinant proteins or enzymes from feedstock without need for pH or conductivity adjustments

Datasheet

MEP HyperCel™ Mixed-Mode Chromatography Resin - Hydrophobic Charge Induction Chromatography | HCIC
en 717.8 kB