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HA Ultrogel® - Hydroxyapatite Chromatography Resin

HA Ultrogel® is a composite material of cross-linked agarose and microcrystalline hydroxyapatite enclosed in the agarose matrix. The material shows mixed mode functionality based on cation exchange and metal affinity in the hydroxyapatite structure. A wide variety of applications include separation of proteins, peptides and nucleic acids, from laboratory to production scale.


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HA Ultrogel® - 500 mL Hydroxyapatite Chromatography Resin
Pack Volume
500 mL
HA Ultrogel®
Resin Format
Bulk resin

HA Ultrogel® resin is a hydroxyapatite agarose composite resin for the separation of biomolecules from research and to manufacturing scale. Hydroxyapatite chromatography is considered to be a “pseudo-affinity” chromatography, or “mixed-mode” ion exchange. It has proven to be an effective purification mechanism in a variety of processes, providing biomolecule selectivity complementary to more traditional ion exchange or hydrophobic interaction techniques.


Features and Benefits

- Unique selectivity and separation mechanism, complementary to traditional IEX and HIC
- Protein purification in neutral, non-denaturating conditions
- High porosity, easy cleaning



- Purification of human serum proteins
- Purification of basic proteins, of phosphate-dependent proteins and enzymes, and of DNA-dependent enzymes
- Vaccine purification processes, e.g. Bordetella pertussis toxin
- Separation of plant proteins such as  lectins, glycoproteins, glycosidases, phospholipidases, sulfohydrolases, sphingomyelinases, transferases, trehalases and kinases


Available Formats for HA Ultrogel®

Pack SizeOrder Code
25 mL24775-082
100 mL24775-025
500 mL24775-017
1 L24775-041
10 L24775-058
20 L24775-066


HA Ultrogel® Hydroxyapatite Chromatography Resin
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