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Sartobind® Q

Sartobind® Q strong ion exchangers are perfect tools for the polishing of monoclonal antibodies for the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins. As size exclusion effects are neglectible, they are suited for purification of viruses such as adeno or lentiviruses displaying one order of magnitude higher dynamic binding capacity.

 

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Products (32)

Sartobind® Q 75
Item no.
93IEXQ42DB-12--V
Bed Height
4 mm
Bed Volume
2.1 mL
Sartobind® Q 100
Item no.
93IEXQ42BC-12
Bed Height
1.4 mm
Bed Volume
2.8 mL
Sartobind® Q 0.8 L, 4 mm, 1 cassette, γ
Item no.
98IEXQ42DGL
Bed Height
4 mm
Bed Volume
0.8 L
Connectors
Sanitary 1 – 1 ½" via Manifold
Sartobind® Q 1.6 L, 8 mm, 1 cassette, γ
Item no.
98IEXQ42EGP
Bed Height
8 mm
Bed Volume
1.6 L
Membrane Adsorber Format
Cassettes
Connectors
Sanitary 1 – 1 ½" via Manifold
Sartobind® Q 96-Well Plates, 10 units
Item no.
99IEXQ42GC-----D
Bed Height
0.8 mm
Bed Volume
19 µL/well
Membrane Adsorber Format
96-Well Plates
Connectors
N/A
Sartobind® Q 400 mL, 8 mm bed height
Item no.
96IEXQ42E1HSS
Bed Height
8 mm
Bed Volume
400 mL
Membrane Adsorber Format
Capsules
Connectors
Sanitary 1 – 1 ½"
Sartobind® Q 150 mL, 8 mm bed height
Item no.
96IEXQ42E9BFF
Bed Height
8 mm
Bed Volume
150 mL
Membrane Adsorber Format
Capsules
Connectors
Sanitary ½ – ¾"
Sartobind® Q Jumbo 5 L, 8 mm bed height
Item no.
96IEXQ42E3ESS
Bed Height
8 mm
Bed Volume
5,000 mL
Connectors
Sanitary 1 – 1 ½"
Sartobind® Q 75 mL, 4 mm bed height
Item no.
96IEXQ42D9MFF--A
Bed Height
4 mm
Bed Volume
75 mL
Connectors
Sanitary ½ – ¾"
Sartobind® Q Nano 1 mL, 4 mm bed height, 1 unit
Item no.
96IEXQ42DN-11
Bed Height
4 mm
Bed Volume
1 mL
Membrane Adsorber Format
Capsules
Connectors
Luer female connectors
Sartobind® Q 75 mL, 4 mm bed height
Item no.
96IEXQ42D9MOO--A
Bed Height
4 mm
Bed Volume
75 mL
Connectors
Hose barb
Sartobind® Q Nano 1 mL, 4 mm bed height, 4 units
Item no.
96IEXQ42DN-11--A
Bed Height
4 mm
Bed Volume
1 mL
Membrane Adsorber Format
Capsules
Connectors
Luer female connectors
Sartobind® Q Nano 3 mL, 8 mm bed height
Item no.
96IEXQ42EUC11--A
Bed Height
8 mm
Bed Volume
3 mL
Membrane Adsorber Format
Capsules
Connectors
Luer female connectors
Sartobind® Q 1.2 L, 8 mm bed height
Item no.
96IEXQ42E3FSS
Bed Height
8 mm
Bed Volume
1,200 mL
Membrane Adsorber Format
Capsules
Connectors
Sanitary 1 – 1 ½"
Sartobind® Q 800 mL, 8 mm bed height
Item no.
96IEXQ42E2LSS
Bed Height
8 mm
Bed Volume
800 mL
Membrane Adsorber Format
Capsules
Connectors
Sanitary 1 – 1 ½"
Sartobind® Q Mini 20 mL, mini TC
Item no.
96IEXQ42E4JFF--A
Bed Height
8 mm
Bed Volume
20 mL
Connectors
Sanitary ½ – ¾"
Sartobind® Q Mini 20 mL, hose barb
Item no.
96IEXQ42E4JOO--A
Bed Height
8 mm
Bed Volume
20 mL
Connectors
Hose barb ½"
Sartobind® Q Mini 20 mL, Luer
Item no.
96IEXQ42E4J11--A
Bed Height
8 mm
Bed Volume
20 mL
Connectors
Luer female connectors
Sartobind® Q 96-Well Plates, 2 units
Item no.
99IEXQ42GC-----V
Bed Height
0.8 mm
Bed Volume
19 µL/well
Membrane Adsorber Format
96-Well Plates
Connectors
N/A
Sartobind® Q Cassette 0.8 L, 4 mm bed height
Item no.
98IEXQ42D-L
Bed Height
4 mm
Bed Volume
0.8 L
Membrane Adsorber Format
Cassettes
Connectors
Sanitary 1 – 1 ½" via Manifold
Results per page: | |

Sartobind® Q membrane adsorbers display a macro-porous structure with pore size of > 3 µm. Quaternary ammonium ligands are bound covalently to the complete internal surface of the membrane, resulting in separation media of high binding capacity combined with exceptional high flow rates.

Applications virus and VLP capture:

As size exclusion effects are negligible, they are suited for purification of viruses and display one order of magnitude higher dynamic binding capacity compared to resin. Viruses such as adeno- or lentiviruses are captured at high flow rates. The material allows also >100 cycles of re-use without loss of binding capacity.

Benefits capture:

  • High speed purification at 5 - 30 bed volumes per minute
  • No size exclusion effects for large proteins an viruses / VLPs
  • >10fold higher binding capacities compared to conventional resins

Applications flow-through polishing:

Sartobind Q is the perfect tool for the flow-through polishing of valuable proteins such as monoclonal antibodies. The bed volumes can be kept sufficiently small during the removal of viruses, DNA, host cell proteins, leached Protein A, and endotoxins from such pharmaceutical proteins.

Benefits flow-through polishing:

  • Virus clearance > 6 log
  • DNA below detection limit
  • Host cell protein removal > 99 %
  • Endotoxin removal > 5 log
  • Save 80 % of column costs

Easy to use:

  • Plug and play devices from 0.08 mL to 5 L
  • Can be used like a filter
  • Flow rate up to 30 bed volumes/min
  • Re-usable or disposable

Application Note

1000 Cycles Constant Binding Capacity - Sartobind® Q Anion Exchanger
en 416.9 kB
High Throughput Screening Using Membrane Chromatography
en 791.7 kB
Host Cell Protein Removal - A Comparison Between Sartobind STIC® PA and Sartobind® Q
en 282.0 kB
Optimizing Adenovirus Purification Processes - Using Sartobind® Q and STIC PA Anion Exchange Membranes
en 659.3 kB
Endotoxin Removal - Ion Exchange Chromatography With Sartobind® Membrane Adsorbers
en 359.9 kB
Sartobind® Membrane Adsorbers for Capture and Polishing
en 1.1 MB
Virus Purification and Removal - Ion Exchange Chromatography with Sartobind® Membrane Adsorbers
en 522.2 kB
Scale up with Sartobind® Q pico — Miniaturized scaleable format for process developers
en 670.2 kB
DNA Removal Using Sartobind® Q in mAb Purification - Ion Exchange Chromatography With Sartobind® Membrane Adsorbers
en 399.4 kB
DNA Binding On Sartobind STIC® PA Compared to Sartobind® Q - Salt Tolerant Membrane Chromatography
en 599.0 kB

Datasheet

Sartobind® 96-Well Plates - High Throughput Screening With IEX and HIC Membrane Chromatography
en 376.4 kB
Sartobind® pico 0.08 mL — Membrane chromatography tool for process development
en 231.9 kB
Sartobind® Q and S, 4 and 8 mm Bed Height
en 1.2 MB

Flyer

Sartobind® Selection Guide
en 827.1 kB

User Manual

Directions for Use - Sartobind® 96-well plates — IEX (Q, S, STIC PA) and HIC (Phenyl) in 8-strips — For High Throughput Screening Based on Macroporous Membranes, 0.8 mm Bed Height
en 505.7 kB
Sartobind® pico 0.08 mL - Sartobind Q, S, STIC PA and Phenyl membrane adsorbers
en 491.7 kB

Product Information

  • Brand
    Sartobind® Q