CellGenix® rh IL-21 (GMP Grade)

Top Features for Recombinant Human Interleukin-21:

  • Optimal use for expansion of CAR-T, TCR-T, TILs, Treg, and NK cells
  • ADCF Level 2
  • High purity to ensure the safety of your process
  • Available in two different grades (Preclinical and GMP grade)

Preclinical grade:

  • Intended for preclinical ex vivo use
  • Endotoxin Level ≤ 25 EU/mg
  • GMP transferable: Seamless transition from preclinical development to commercial manufacturing

GMP grade:

  • Intended for clinical ex vivo use
  • Endotoxin Level ≤ 25 EU/mg
  • Manufactured in accordance with applicable GMP guidelines
  • FDA Drug Master File (DMF) available
  • Technical and regulatory support available

Price (USD):
Catalog No.: 

*Custom/bulk order quotes are provided within 72 hours of request.

Letter of Authorization (LOA)

Place a request for a Letter of Authorization (LOA) for our Drug Master File (FDA)

CellGenix® rh Cytokines - Preclinical vs GMP

Both product grades are produced under the same conditions in a GMP facility, ensuring an equal product quality and performance. We offer a more comprehensive QC testing including tighter specifications and documentation for our GMP products: CellGenix® rh Cytokines - Preclinical vs GMP

CellGenix® Recombinant Human Interleukin-21 (IL-21) is an animal-derived component-free product. It is produced in a dedicated animal-free GMP facility. IL-21 is used in the cell and gene therapy space for the ex vivo expansion of T cells, including CAR T cells and TCR T cells and natural killer cells (NK cells).

CellGenix® Recombinant Human IL-21 is produced following all applicable GMP guidelines and allows for the safe use in accordance with USP Chapter <1043>, Ph. Eur. General Chapter 5.2.12 and ISO 20399:2022.

CellGenix® GMP cytokines are provided with documented evidence of purity, potency, consistency and stability. In combination with our expert regulatory and technical support this will help simplify your raw material qualification and validation efforts.

Expiry: ≥ 6 months from date of shipping

Please refer to Certificate of Analysis https://my.sartorius.com/login for the exact expiry date and the batch specific activity.

We have submitted Drug Master Files (DMFs) to US Health Authorities to support our customers’ regulatory activities. These Master Files can be cross-referenced through Letters of Authorization (LOAs) in Marketing Authorizations, IND, BLA, NDA, ANDA or other DMF applications. Submit your Authorization Request here https://cellgenix.com/dmf-letter-of-authorization-request-form-2/


App Note:

Reliable T Cell Expansion with CellGenix®️ rh IL-2

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Tech Note:

ADCF and Serum-free Policy

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Tech Note:

Shipment at Ambient Temperatures

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Certificate of Analysis:

Download on the My Sartorius portal

My Sartorius

Tech Note:

Stability of GMP Cytokines after Reconstitution 

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Tech Note:

Batch-to-Batch Consistency of CellGenix® GMP Cytokines

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  • Application
    Clinical ex vivo use (small)
  • Application Area
    • Cell & Gene Therapy
    • Immunology
  • Cell Type
    • T Cells
    • NK Cells

Biological Information

  • Activity
    0.5 – 1.6 x 106 IU/mg

Compliance Information

  • GMP Compliance
    This product was manufactured in accordance with applicable Good Manufacturing Practice (GMP) guidelines.
  • Origin
    Animal-Component Free

Physicochemical Information

  • Endotoxin
    ≤ 25 EU/mg
  • Expression
    E. coli
  • Formulation
    Lyophilized from 200 µl of a 0.2 µm-filtered solution containing 15 mM sodium acetate and 45 mM sodium chloride, pH 5.5

Product Information

  • Brand
  • Package Type


  • Delivery Condition
  • Purity
    ≥ 97%


  • Volume
    50 µg


  • Molecular Weight (kDa)
    15.4 kDa
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