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Celsius® FT33 | 66 | 100

Celsius® FT33 | 66 | 100 is a controlled-rate freeze & thaw system designed to minimize the adverse effects of the cryoconcentration in your biopharmaceutical products. This modular equipment uses a patented heat transfer technology that provides unprecedented freeze and thaw performance and flexibility for processing up to 100 L of solution with single-use Celsius®-Paks.

Item no.:  M_Celsius_FT_33_66_100

The Celsius® FT33 | 66 | 100 is designed for freezing and thawing 1L, 2L, 8.3L and 16.6L Celsius®-Paks.

The system is equipped with:

Freeze & Thaw Module

Because of its modular design, the basic module (Celsius® FT33) can be expanded with up to two additional modules (two modules for Celsius® FT66, and three modules for Celsius® FT100). The Heat Transfer Fluid (HTF) circulates inside heat transfer plates that are mounted on each module. Once a freeze or thaw cycle is initiated, the plates close to the Celsius®-Paks ensuring excellent contact between the plates and the Celsius®-Pak surface optimizing the heat transfer. The Celsius® FT33 | 66| 100 is mounted on rockers that allow the module to rock back and forward during thawing processes. This rocking movement optimizes the mixing of the liquid and solid phases of the product, improving thawing time and ensuring product homogeneity.

Conceived to minimize operator efforts, each module has a docking locator to align the Transfer Cart, the SM100 - Storage Module or the Celsius® SSM to simplify the transfer of the Celsius®-Paks to and from each module.

Temperature Control Unit

The Temperature Control Unit (TCU) allows robust and reproducible freeze and thaw cycles. The TCU controls the freeze and thaw processes by supervising the temperature and flow rate of the heat transfer fluid according to predefined recipes.

Control Cabinet

The entire automatic freeze, thaw and hold operations are processed through the control cabinet. It is linked to the TCU and the freeze and thaw module via Profinet. The critical parameters of all processes are commanded, monitored and stored in an automatic manner with minimal operator intervention. The Human Machine Interface (HMI) is a touch screen panel PC connected to a Siemens PLC. All relevant process values are recorded with the WINCC software.

Features of the Celsius® FT33 | 66 | 100:

  • Controlled cooling plate force
  • Expandable up to three Celsius® FT33 modules
  • The Temperature Control Unit (TCU) may be installed in a separate room
  • Controlled freezing and thawing process steps
  • Dimple jackets for uniform temperature distribution over the cooling plates
  • Removable plates for easy maintenance and cleanability (no need to get access to the rear of the device for maintenance and cleaning)


Discover our freezeing capabilities Celsius product lines
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Celsius CFT The controlled-rate F&T Platform Technology
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Celsius FT33|66|100
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Celsius CFT: safeguarding your drug substances in controlled-rate FT manufacturing
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Article in the PDA Journal
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Bulk Freeze-Thawing of Macromolecules published in BioProcess technical
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Scale up case study for long term storage of a process intermediate in bags
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Large Freezing of Biologics - BioProcess Technical
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Accessories Information

  • Software
    Based on ISA-S88 standard, 21CFR Part11 & GAMP5 compliance


  • Area of Application
    Frozen Storage & Shipping
  • Process Step
    • Cell Harvest & Downstream Processing Intermediates
    • Drug Substance Purification
    • Drug Product Formulation

Connections (Data)

  • Data Interface
    Profibus DP/Profinet with remote I/Os and other fieldbus


  • Languages
    English and German; other languages upon request
  • Load Capacity
    4× 8.3 L or 2× 16.6 L Celsius®-Pak or 2× Carrier (per FT module); 12× 8.3 L or 6× 16.6 L Celsius®-Pak or 6× Carrier (for a complete FT100 System)
  • Use with
    1 L; 2 L; 8.3 L & 16.6 L Celsius®-Pak

Materials of Construction

  • Materials of Construction
    FT module: 1.4301 / 1.4430 / 1.4571 stainless steel

Power Requirements

  • Power Requirements
    3~N | 400 V | 50 Hz or 3~N | 460 V | 60 Hz

Product Information

  • Primary Product Type
    Freeze & Thaw Systems


  • Additional Product Specifications
    Control Unit: Siemens PLC (S7 type 300/400), Simatic WinCC V7 runtime software with connectivity package (SCADA system)
  • Condition of Use
    5–35°C | Relative Humidity <80%
  • Installation Requirements
    Compressed air (6 to 10 barg) & coolant water (1 to 6 barg in- and 6 to 10 barg outlet | differential pressure > 1 barg)
  • Temperature Range
    -60°C – +35°C


  • Working Volume
    0.25 L – 100 L


  • Weight
    Refer to the datasheet