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Celsius® Pak 2L (MPC/MPC/MPC)

Celsius® CFT (Controlled Freeze & Thaw) is an industry-leading platform technology that controls the freezing and thawing rate to minimize cryo-concentration in biopharmaceutical products.

This robust and reliable platform ensures drug substances are well-protected from start to finish, and offers process flexibility by processing up to 100 L of solution in single-use Celsius® Paks. Qualified transfer, storage and shipping solutions are offered as part of the complete frozen logistics.

Item no.:  FZB129259


* 72 Hours Turnaround Time

Celsius® CFT is a platform technology for controlled-rate freezing and thawing of biopharmaceutical products. Celsius® CFT features Celsius® Paks that are sterile, pre-assembled and ready to use single-use bags purposely engineered to fit into reusable structural frames. Celsius® CFT defeats cryo-concentration during freeze & thaw cycles. Celsius® CFT processes up to 100L of product per cycle in the Celsius® FT100 system, and offers well-qualified shipping solutions for transferring the frozen drug substances around the world.

Maximum Product Security:

  • Extensive functional qualification in real process conditions
  • Optimized logistics from fill through drain
  • Defeat cryoconcentration and stabilize drug substances

Excellent Process Reliability:

  • Total integration with monitoring of critical process parameters and process control
  • Pre-qualified shipper (ASTM D4169 AL1 mechanical ISTA7D extreme summer thermal performances)
  • Excellent reproducibility of the freeze and thaw cycles

Creates Process Flexibility:

  • Improves production management
  • Facilitate any process transfer
  • Reduce process time with fast freeze and thaw processes


  • In performances: Benchtop (30mL) to production (100L)
  • In capacity: Flexible production platform (33L with Celsius® FT33, 66L with Celsius® FT66 or 100L with Celsius® FT100)
  • In contact material: Same film for all Celsius® products for easy scale-up

The versatile range of Celsius® Pak Pre-Designed Solutions (PDS) provide single-use freeze & thaw solutions for every process step when frozen storage and frozen shipment are required. Celsius® Pak PDS are configured with the features needed to decouple downstream process steps and securely transport drug substances to drug product sites.

Celsius® Pak PDS are qualified against extensive biological, chemical,physical, extractable and functional testing. You can use our intuitive digital brochure to select your Celsius® Pak PDS in a few seconds. PDS help speed up process design, reduce the numbers of stock keeping units (SKU’s) and hence reduce inventory management complexity and costs.

The performance and assurance of supply of PDS are based on the complete control of our manufacturing process for the resins, the film, the bags, the filters and the assemblies. Other fluid-contact components are secured by strategic partnerships, long term contracts and quality agreements and are available off-the-shelf to provide best delivery reliability.

Celsius® Pak are available in sizes of 1 L, 2 L, 8.3 L and 16.6 L nominal fill volume and feature a variety of connections to allow fluid transfer across the entire drug manufacturing process.

Inlet and outlet connectors

  • Opta® SFT Male enables sterile connections to other single-use systems
  • CPC quick couplers are used for either sanitary connection or aseptic connection under ISO5 laminar air flow to single-use systems
  • Press in plug equipped with clear C-Flex® for sterile weld connection with BioWelder® TC and sterile seal disconnection with BioSealer®

Celsius® Pak feature a venting line which is used after filling to pressurize the Celsius® Pak with air or nitrogen to guarantee performances of the controlled-rate freeze and thaw process:

  • Midisart® BV Air Filter for sterile venting
  • CPC quick couplers are used for non-aseptic venting with sanitary connection


For non-invasive product temperature measurement during freezing and thawing operations, Celsius® Pak are equipped with a thermowell, a sealed-end EVA tube with a luer connector to monitore critical process parameters at the last point to freeze.


  • Liveo™ Pharma 50 silicone tubing
  • Clear C-Flex® tubing allows for sterile weld connection with BioWelder® TC and sterile seal disconnection with BioSealer®
  • EVA tubing enables sterile seal disconnection with Vante™ sealer

All fluid-contact components of Celsius® Pak PDS are secured by supply contracts and quality agreements to provide:

  • Best quality, change control and business continuity with at least 24 months change notification
  • Best delivery reliability with available stocks
  • Compliance to quality standards such as USP <87> and USP <88>, TSE-BSE, REACH

Compliance Information

  • Biocompatibility (USP Class VI)
    USP and ISO 10993-5; USP
  • Extractables
    Extractable data readily available
  • Physico-chemical Compatibility
    USP and EP 3.1.7
  • Quality Standards
    ISO 9001 and ISO 13485 for medical devices

Connections (Physical)

  • Venting Lines
    MPC Male + Sealing Cap + 1/4" ID ‎Silicone (Liveo™ Pharma 50) 0.1 m (4")

General Specifications

  • Temperature Range
    -70°C – +45°C (for use at lower temperatures contact Sartorius)

Product Information

  • Brand
    Celsius® Pak
  • Freezer Technology
    Vertical plate freezing
  • Pack Size


  • Delivery Condition


  • Volume
    2 L
  • Working Volume
    0.5 L – 2L
Transfer Cart, 33L
Item no.

The Transfer Carts are designed to minimize the operator efforts when transferring Celsius® Paks between the equipment and accessories of the Celsius® CFT platform.

Transfer Cart, 100L
Item no.

The Transfer Carts are designed to minimize the operator efforts when transferring Celsius® Paks between the equipment and accessories of the Celsius® CFT platform.

Celsius® Pak 1 L and 2 L Carrier
Item no.

The Celsius® Pak Carrier allows processing the 1L or 2L Celsius® Paks in the Celsius® FT33 | 66 | 100. The Celsius® Pak Carrier can receive up to height 1L Celsius® Paks, four 2L Celsius® Paks, or a mix of each.