SARTOFLOW®10, 1.4435/F/R23/P23, JIS-G, e-polished
The SARTOFLOW® 10 stainless steel holder with hydraulic is designed for crossflow applications from 30 L to 1000 L volume. The holder is optimised for the use with up to ten Sartocon® or two Sartocube® production scale crossflow cassettes (max. 7 m²). Typical applications of the SARTOFLOW® 10 holder are concentration and diafiltration of proteins, vaccines, antibodies, oligo nucleotides, endotoxin removal etc. and cell harvesting and clarification processes.
Item no.: 179-6DJ230230E
SARTOFLOW® 10 is a crossflow filtration holder used in biopharmaceutical crossflow applications.
By selecting the appropriate membrane, you can use it for such applications as cell separation or cell concentration down to protein or enzyme purification. The SARTOFLOW® 10 filter holder can accommodate up to 10 Sartocon® filter cassettes. Pressure is applied by means of a pneumatically powered or manually operated hydraulic pump to a sliding clamping plate through a centered hydraulic ram.
The cassettes are positioned between the sliding clamping plate and the stationary product plate. All parts that come into contact with the filtered product are manufactured from highly polished stainless steel (Ra ≤ 0.4 μm), which makes cleaning simple and easy.
The polished finish of the clamping plates and the product plate ensures perfect sealing of the filter cassettes while in use.
This design has several advantages:
- smooth and safe operation when using a pneumatically driven hydraulic pump;
- no need for seals between the cassettes and the clamping plates;
- simple cassette exchange procedure;
- filter holder is in-line steam-sterilizable.
Connectors1" - 1½" Tri Clamp sanitary flange (DN25)
Dimensions (W×D×H)240 × 348 × 695 mm
Feed / Retentate23 mm
Materials of Construction
Filter- and Clamping Plate Material316L (1.4435) stainless steel
Maximum Operating Pressure4 bar (58 psi)
Cassette CapacitySartocon® Cassettes: ≤ 10
Electro PolishedElectro Polished
Surface Roughness of Wetted PartsRa <= 0.4 µm
Weight (approximate)70 kg
Hydrosart® membranes are extremely hydrophilic, making it non-protein binding and virtually non-fouling. Hydrosart® mikrofiltration cassettes are available in 0.2 µm and 0.45 µm.
Hydrosart® high performance membrane is a stabilized cellulose based membrane that has been optimized for biopharmaceutical process applications. Hydrosart® is stable across a broad pH range, is extremely hydrophilic, making it non-protein binding, and virtually non-fouling. Membrane cleaning, storage and depyrogenation can be accomplished by using NaOH even at elevated temperatures and concentrations. These features make Hydrosart® an ideal membrane for biological applications.
PESU cassettes are available in 0.1 µm pore size. Polyethersulfone membranes are designed for applications in the biotechnological and pharmaceutical industries. They can be used to remove the following cells from liquids:
- Mammalian cells
- Mycoplasma reduction
Polyethersulfone membranes (PESU) are stable polymer that feature a broad pH and temperature range. Polyethersulfone ultrafiltration cassettes are available in the following nominal molecular weight cutoffs:
- 1 kD
- 5 kD
- 8 kD
- 10 kD
- 30 kD
- 50 kD
- 100 kD
- 300 kD