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Virosart® Media lab module 5.0 cm²

First virus retentive filter for cell culture media.

Protect your cell culture media from virus contaminations with the 20 nm high flux PES Virosart® Media. The filter retains ≥ 4 LRV for small non-enveloped viruses like MVM or Vesivirus and ≥ 6 LRV for large enveloped viruses.

Item no.:  3V2--28-BVGML--V

Availability (ex works):  On Request



  • Virus clearance: Virosart® Media targets the removal of small non-enveloped adventitious viruses (20 nm) e.g. MVM or vesivirus from chemically defined cell culture media.
  • Target molecule: The main application for Virosart® Media is virus retentive filtration of chemically defined cell culture media.
  • Positioning: Virosart® Media is used after the media preparation step itself before transferring the media into the bioreactor. This can be operated either as in-line filtration (e.g. perfusion) or batch filtration. Performance of the Virosart® Media is independent of the use of powder or liquid media but could be strongly impacted by the media itself. Virosart® Media is optimized for chemically defined media. Protein transmission for mAbs and recombinant proteins is not given for this filter.

Product benefits:

  • Robust virus clearance: Virosart® Media provides high virus safety to the bioreactor as it is qualified for ≥ 4 LRV (Log10 reduction value) of small non-enveloped viruses (e.g. MVM) and ≥ 6 LRV for large enveloped viruses.
  • Short processing times: Based on the optimized Polyethersulfone membrane, Virosart® Media provides highest flow rates and excellent capacity for cell culture media (e.g. ≥ 1000 L/m2 in 4 h).
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up with low footprint requirements. 
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® HF are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual module is tested for water flow rate during manufacturing 
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins
  • USP Plastic Class Test VI

Application Note

Influence of Cell Culture Media Components on the Filtration Characteristics of Virosart® Media
en 354.0 kB
Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 1.5 MB
Retention Characteristics of Virosart® Media when filtering Chemically Defined Cell Culture Media
en 591.5 kB
Evaluation of Impact on Cell Growth using Chemically defined Cell Culture Media filtered through the Virosart® Media Filter
en 1.0 MB
Evaluating the Filterability of Chemically Defined Cell Culture Media with the Virosart® Media Filter
en 1.8 MB
Evaluating the Robustness of Virus Clearance under Challenging Filtration Conditions using the Virosart® Media Filter
en 230.9 kB
Evaluating Lot-to-Lot Performance Consistency of Chemically Defined Cell Culture Media during filtration with the Virosart® Media Filter
en 871.3 kB


Virosart® Media - Upstream Virus Retentive Filter
en 932.7 kB


Virosart® Virus Filters - Reliable Retention Under All Circumstances
en 2.8 MB


Case Study: Virus Risk Mitigation in Cell Culture Media
en 1.0 MB
Contamination Risk Mitigation in Cell Culture Media Preparation
en 1.2 MB

User Manual

Virosart® Media Lab Module
en 145.5 kB


  • Usage
    Cell culture risk mitigation

Connections (Physical)

  • Connector Inlet
    Luer Lock
  • Connector Outlet
    Luer Lock


  • Filtration Area
    5 cm²
  • Height
    180 mm


  • Integrity Tested

General Specifications

  • Capsule/Cartridge Format
    Down scale unit
  • Filter Format
    Down Scale Units

Product Information

  • Filter Type
    Virus Filters
  • Primary Product Type


  • Delivery Condition
    Sterile - Gamma irradiated