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Virosart® Media lab module 5.0 cm²

First virus retentive filter for cell culture media.

Protect your cell culture media from virus contaminations with the 20 nm high flux PES Virosart® Media. The filter retains ≥ 4 LRV for small non-enveloped viruses like MVM or Vesivirus and ≥ 6 LRV for large enveloped viruses.

Item no.:  3V2--28-BVGML--V

Availability (ex works):  On Request


  • Virus clearance: Virosart® Media targets the removal of small non-enveloped adventitious viruses (20 nm) e.g. MVM or vesivirus from chemically defined cell culture media.
  • Target molecule: The main application for Virosart® Media is virus retentive filtration of chemically defined cell culture media.
  • Positioning: Virosart® Media is used after the media preparation step itself before transferring the media into the bioreactor. This can be operated either as in-line filtration (e.g. perfusion) or batch filtration. Performance of the Virosart® Media is independent of the use of powder or liquid media but could be strongly impacted by the media itself. Virosart® Media is optimized for chemically defined media. Protein transmission for mAbs and recombinant proteins is not given for this filter.

Product benefits:

  • Robust virus clearance: Virosart® Media provides high virus safety to the bioreactor as it is qualified for ≥ 4 LRV (Log10 reduction value) of small non-enveloped viruses (e.g. MVM) and ≥ 6 LRV for large enveloped viruses.
  • Short processing times: Based on the optimized Polyethersulfone membrane, Virosart® Media provides highest flow rates and excellent capacity for cell culture media (e.g. ≥ 1000 L/m2 in 4 h).
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up with low footprint requirements. 
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® HF are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual module is tested for water flow rate during manufacturing 
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins
  • USP Plastic Class Test VI

Application Note

Evaluating Lot-to-Lot Performance Consistency
en 880.0 kB
Evaluating the Robustness of Virus Clearance
en 239.5 kB
Influence of Cell Culture Media Components on the Filtration Characteristics of Virosart® Media
en 354.0 kB
Retention Characteristics of Virosart® Media when filtering Chemically Defined Cell Culture Media
en 591.5 kB
Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 1.5 MB
Evaluation of Impact on Cell Growth using Chemically defined Cell Culture Media filtered through the Virosart® Media Filter
en 1.0 MB
Evaluating the Filterability of Chemically Defined Cell Culture Media with the Virosart® Media Filter
en 1.8 MB


Virosart® Media
en 394.5 kB


Virosart® — Highest virus safety for your patient — Next generation virus clearance concepts
en 886.6 kB


Contamination Risk Mitigation in Cell Culture Media Preparation
en 563.2 kB
Case Study: Virus Risk Mitigation in Cell Culture Media
en 671.3 kB
New Solutions for Virus Risk Mitigation in Cell Culture Media
en 1.0 MB

User Manual

Virosart® Media Lab Module
en 145.5 kB


  • Usage
    Cell culture risk mitigation

Connections (Physical)

  • Connector Inlet
    Luer Lock
  • Connector Outlet
    Luer Lock


  • Filtration Area
    5 cm²
  • Height
    180 mm


  • Integrity Tested

Product Information

  • Filter Type
    Virus Filters
  • Primary Product Type


  • Capsule/Cartridge Format
    Down scale unit
  • Filter Format
    Down Scale Units