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HEA HyperCel - 100 mL

HEA HyperCel is a mixed-mode resin with a less hydrophobic hexylamine ligand allowing protein binding at a moderate salt concentration under neutral pH.

Item no.:  20250-033


HEA HyperCel resin is an industry-scalable chromatography resin designed for protein capture and impurity removal in a biopharmaceutical environment. Operating on a “mixed-mode” mechanism, with a hexylamine ligand, its behavior is based on a combination of electrostatic and hydrophobic interactions of the proteins with the ligands. HEA HyperCel resin provides unique selectivities, different from those given by ion exchange or conventional HIC (hydrophobic interaction chromatography).


Features and Benefits

- High mechanical and chemical stability
- Suitable for large-scale chromatography in a biopharmaceutical environment
- Cross-linked cellulose base matrix


- Protein purification at low ionic strength by direct hydrophobic capture
- Separation of challenging mixtures, e.g. protein isoforms or proteins with very close pIs
- Orthogonal separation mechanism to ion exchange or HIC


Available Formats for HEA HyperCel

Pack SizeOrder Code
25 mL20250-026
100 mL20250-033
1 L20250-041
5 L20250-042
10 L20250-056


As pre-packed columns:

Pack SizeOrder Code
1 mL PRC Prepacked Column, 5 mm ID x 50 mmPRC05X050HEAHCEL
5 mL PRC Prepacked Column, 8 mm ID x 100 mmPRC08X100HEAHCEL
RoboColumn HEA HyperCel 200 μL, row of 8SR2HEA
RoboColumn HEA HyperCel 600 μL, row of 8SR6HEA



HEA and PPA Hypercel Resins
en 832.1 kB


  • Application
    Preparative protein purification

Compliance Information

  • Quality Standards
    CoA, RSF

General Specifications

  • Flow Rate

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)
  • pH Stability
    1 to 14 (short term); 2 to 12 (long term)

Physicochemical Information

  • Ligand
  • Reference Protein
  • Typical Dynamic Binding Capacity 10% per mL
    40-60 mg/mL BSA

Product Information

  • Pack Size
  • Primary Product Type
  • What you receive
    1 bottle resin, instructions