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CMM HyperCel 10 L - Mixed-Mode Cation Exchange Resin

CMM HyperCel is a hydrophobic cation exchanger designed for the capture of antibodies, antibody fragments, and recombinant proteins. It allows the separation of proteins with similar pIs and hydrophobicity by modulation of pH and conductivity.

Item no.:  20270-066


CMM HyperCel resin is composed of a rigid cellulose matrix that has flow properties compatible with the needs of manufacturing scale protein production.
The proprietary ligand, containing both a primary amine and a carboxyl group, confers cation exchange and hydrophobicity properties to the chromatography resin. The flexibility of the ligand enables the separation of proteins with a large variety of isoelectric points and hydrophobicity levels, and multiple conditions can be employed to separate targeted molecules from contaminants.


Features and Benefits

- Unique selectivity
- High capacity mixed-mode chromatography resin
- High recovery, low elution volume
- Easy CIP, NaOH stable



- Capture of MAbs, Fab fragments and recombinant proteins from challenging feedstocks
- Separation of proteins with similar isoelectric point and | or hydrophobicity at low or high conductivity


Available Formats for CMM HyperCel

Pack SizeOrder Code
25 mL20270-025
100 mL20270-031
1 L20270-041
5 L20270-055
10 L20270-066


 As pre-packed columns:

Pack SizeOrder Code
PRC Column 5x50 CMM HyperCel, 1 mLPRCCMMHCEL1ML
PRC Column 8x100 CMM HyperCel, 5 mLPRCCMMHCEL5ML
RoboColumn CMM HyperCel 200 µLSR2CMM
RobocolumnCMM HyperCel 600 µLSR6CMM



en 1.4 MB


  • Application
    Preparative protein purification

Compliance Information

  • Quality Standards
    CoA, RSF


  • Bead Size
    50 - 80 µm

General Specifications

  • Flow Rate
  • Resin Format
    Bulk resin

Materials of Construction

  • Base Matrix
    Rigid cellulose beads

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)
  • pH Stability
    1 to 14 (short term); 2 to 13 (long term)

Physicochemical Information

  • Ligand
    aminobenzoic acid
  • Reference Protein
    BSA / IgG
  • Typical Dynamic Binding Capacity 10% per mL
    > 50 mg/mL BSA at pH 4.5, 15 mS/cm; 60-100 mg/mL IgG at pH 4 to 5, 4-12 mS/cm

Product Information

  • Pack Size
  • Pack Volume
    10 L
  • Primary Product Type
  • Resin Delivery Condition
    1M NaCl with 20% EtOH
  • Resin Type
    Mixed-mode cation exchanger
  • What you receive
    1 bottle resin, instructions

Storage Conditions

  • Storage Conditions
    20% EtOH/1 M NaCl