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MEP HyperCel™ Mixed-Mode Chromatography Resin

MEP HyperCel™ provides unique selectivity for monoclonal antibody capture or polishing to remove aggregates, HCP, and DNA. The ligand facilitates the binding of target proteins at neutral pH under moderate salt concentrations. 

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MEP HyperCel™ is a flexible mixed-mode chromatography resin designed for capture and purification of antibodies and various recombinant proteins from laboratory to manufacturing scale.

MEP HyperCel resin offers a no salt/low salt alternative to conventional HIC and can simplify processes and improve economics by removing the need for salt addition and following UF/DF steps. The MEP ligand is immunoglobulin-selective. Thus, MEP Hypercel can be effectively used for IgG capture and for enhanced DNA, HCP and aggregate removal. Elution is under mild conditions.


Features and Benefits

- Unique separation mechanism and differentiated selectivity
- Direct protein capture from a variety of feedstocks
- No salt addition required for binding means a simpler process, lower costs and reduced waste
- Stable toward harsh cleaning with NaOH


- A no-salt/low-salt alternative to Hydrophobic Interaction Chromatography (HIC)
- Monoclonal and polyclonal IgG capture and intermediate purification (aggregate, DNA and HCP removal)
- Direct capture of recombinant proteins or enzymes from feedstock without need for pH or conductivity adjustments

Available formats for MEP HyperCel resin

Pack SizeOrder Code
25 mL12035-010
100 mL12035-028
1 L12035-036
5 L12035-040
10 L12035-044


 As pre-packed columns:

Pack SizeOrder Code
PRC Column 5x50 MEP HyperCel, 1 mLPRC05X050MEPHCEL
PRC Column 8x100 MEP HyperCel, 5 mLPRC08X100MEPHCEL
RoboColumn MEP HyperCel 200µLSR2MEP
RoboColumn MEP HyperCel 600µLSR6MEP



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