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HEA HyperCel - Mixed-mode Chromatography Resin

HEA HyperCel is a mixed-mode resin with a less hydrophobic hexylamine ligand allowing protein binding at a moderate salt concentration under neutral pH.

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HEA HyperCel resin is an industry-scalable chromatography resin designed for protein capture and impurity removal in a biopharmaceutical environment. Operating on a “mixed-mode” mechanism, with a hexylamine ligand, its behavior is based on a combination of electrostatic and hydrophobic interactions of the proteins with the ligands. HEA HyperCel resin provides unique selectivities, different from those given by ion exchange or conventional HIC (hydrophobic interaction chromatography).

 

Features and Benefits

- High mechanical and chemical stability
- Suitable for large-scale chromatography in a biopharmaceutical environment
- Cross-linked cellulose base matrix


Applications

- Protein purification at low ionic strength by direct hydrophobic capture
- Separation of challenging mixtures, e.g. protein isoforms or proteins with very close pIs
- Orthogonal separation mechanism to ion exchange or HIC

 

Available Formats for HEA HyperCel

Pack SizeOrder Code
25 mL20250-026
100 mL20250-033
1 L20250-041
5 L20250-042
10 L20250-056

 

As pre-packed columns:

Pack SizeOrder Code
1 mL PRC Prepacked Column, 5 mm ID x 50 mmPRC05X050HEAHCEL
5 mL PRC Prepacked Column, 8 mm ID x 100 mmPRC08X100HEAHCEL
ScreenExpert RoboColumn HEA HyperCel 200 μL, row of 8SR2HEA
ScreenExpert RoboColumn HEA HyperCel 600 μL, row of 8SR6HEA

 

Datasheet

HyperCel-HEA-PPA-Datasheet-en-B-2578760-Sartorius.pdf
en 1.7 MB