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CM Ceramic HyperD® F, PRC Column 5 x 50, 1 mL Ion Exchange Chromatography Resin

CM Ceramic HyperD® is a weak cation exchanger for biomolecule purification. Changes in conductivity and pH can optimize purification steps by utilizing the charge change on protein and ligand. Pre-packed columns simplify resin screening and selection, and are ideal for process step optimization. The RoboColumn format is especially suited to high throughput process development (HTPD).

Item no.:  PRC05X050CMCHDF


CM Ceramic HyperD® F ion exchange chromatography resin is designed using proprietary 'gel-in-a-shell' design that provides rapid mass transfer and effective binding. It relies on a high capacity hydrogel, polymerized within the gigapores of a rigid ceramic bead.


Features and Benefits

- High dynamic binding capacity at high flow rates
- Truly rigid, non-compressible resin
- Salt tolerant CM Ceramic HyperD™ F resin reduces Ultrafiltration/Diafiltration (UF/DF) requirements



- Recombinant proteins
- Purification of enzymes, plasma proteins
- Vaccines
- Direct capture of monoclonal antibodies
- IgM


Available formats for CM Ceramic HyperD® resin 

Pack SizeOrder Code
25 mL20050-035
100 mL20050-027
1 L20050-019
5 L20050-050
10 L20050-043

As pre-packed columns:

Pack SizeOrder Code
PRC Column 5x50 CM Ceramic HyperD FPRC05X050CMCHDF
RoboColumn CM Ceramic HyperD F 200µlSR2CMCHDF
RoboColumn CM Ceramic HyperD F 600µlSR6CMCHDF


Ceramic Hyper D Q, DEAE, CM Datasheet
en 799.2 kB


  • Application
    Resin screening and process optimization

Compliance Information

  • Quality Standards
    CoA, RSF


  • Bead Size
    50 µm
  • Bed Height
    50 mm
  • Dimensions
    5 x 50 mm

General Specifications

  • Flow Rate
    typically 300 to 600 cm/h (1 to 2 mL/min) with < 1.5 bar (22psi)
  • Resin Format
    Pre-packed column

Materials of Construction

  • Base Matrix
    Ceramic Beads
  • Materials of Construction

Operating Conditions

  • Operating Pressure
    < 3 barg (44psi)
  • pH Stability
    1 to 14 (short term); 2 to 12 (long term)

Physicochemical Information

  • Bed Volume
    1 mL
  • Ligand
  • Ligand Density
    250-400 µeq/mL
  • Reference Protein
  • Typical Dynamic Binding Capacity 10% per mL
    > 60 mg/mL hIgG

Product Information

  • Pack Size
    1 column per pack
  • Pack Volume
    1 mL
  • Primary Product Type
    Pre-packed column
  • Resin Delivery Condition
    20% EtOH/150 mM NaCl
  • Resin Type
    Weak cation exchanger
  • What you receive
    1 column, instructions

Storage Conditions

  • Storage Conditions
    20% EtOH/1 M NaCl