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Virosart® Media 1.0 m² - Non-sterile Delivery

First virus retentive filter for cell culture media.

Protect your cell culture media from virus contaminations with the 20 nm high flux PES Virosart® Media. The filter retains ≥ 4 LRV for small non-enveloped viruses like MVM or Vesivirus and ≥ 6 LRV for large enveloped viruses.

Item no.:  3V2--28-IV-SF

Availability:  On Request



  • Target molecule: The main application for Virosart® Media is virus retentive filtration of chemically defined cell culture media.
  • Virus clearance: Virosart® Media targets the removal of small non-enveloped adventitious viruses (20 nm) e.g. MVM or vesivirus from chemically defined cell culture media.
  • Positioning: Virosart® Media is used after the media preparation step itself before transferring the media into the bioreactor. This can be operated either as in-line filtration (e.g. perfusion) or batch filtration. Performance of the Virosart® Media is independent of the use of powder or liquid media but could be strongly impacted by the media itself. Virosart® Media is optimized for chemically defined media. Protein transmission for mAbs and recombinant proteins is not given for this filter.

Product benefits:

  • Robust virus clearance: Virosart® Media provides high virus safety to the bioreactor as it is qualified for ≥ 4 LRV (Log10 reduction value) of small non-enveloped viruses (e.g. MVM) and ≥ 6 LRV for large enveloped viruses.
  • Short processing times: Based on the optimized Polyethersulfone membrane, Virosart® Media provides highest flow rates and excellent capacity for cell culture media (e.g. ≥ 1000 L/m2 in 4 h).
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up with low footprint requirements.
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® Media are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual module is tested for integrity and for water flow rate during manufacturing
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins
  • USP Plastic Class Test VI

Application Note

Influence of Cell Culture Media Components on the Filtration Characteristics of Virosart® Media
en 716.7 kB
Retention Characteristics of Virosart® Media When Filtering Chemically Defined Cell Culture Media
en 831.2 kB
Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 686.5 kB
E valuation of Impact on Cell Growth Using C hemically Defined Cell Culture Media Filtered Through the Virosart® Media Filter
en 1.1 MB
Evaluating the Filterability of Chemically Defined Cell Culture Media With the Virosart® Media Filter
en 1.1 MB
Evaluating Lot-to-Lot Performance Consistency of Chemically Defined Cell Culture Media During Filtration With the Virosart® Media Filter
en 1.4 MB
Evaluating the Robustness of Virus Clearance Under Challenging Filtration Conditions Using the Virosart® Media Filter
en 525.7 kB


Virosart® Media - Upstream Virus Retentive Filter
en 932.7 kB
Virus Filter Transfer Units (Gamma)
en 691.8 kB


Virosart® Virus Filters - Reliable Retention Under All Circumstances
en 2.8 MB


Contamination Risk Mitigation in Cell Culture Media Preparation
en 1.2 MB
Case Study: Virus Risk Mitigation in Cell Culture Media
en 1.0 MB

User Manual

Directions for Use - Virosart ® Media Process Modules
en 401.1 kB

Connections (Physical)

  • Connector Inlet
    1½" Tri-Clamp 50 mm
  • Connector Outlet
    ¾" Tri-Clamp 25 mm


  • Filtration Area
    1.0 m² | 10.8 ft²


  • Integrity Tested

General Specifications

  • Capsule/Cartridge Format
    Filter capsule
  • Filter Format
    Filter Capsules

Physicochemical Information

  • Pore Size
    20 nm (nominal)

Product Information

  • Filter Type
    Virus Filters


  • Delivery Condition
    Non sterile - Gamma irradiatable
Sartopore® 2 XLM T-Style Maxicaps®

Sartopore® 2 is the industry standard of high-performance polyethersulfone (PES) liquid filters. A broad variety of different pore size combinations ensures highly economic and safe filtration performance. From single-layer high flow solutions to specific Mycoplasma retentive filters, Sartopore®2 perfectly adapts to your specific process needs.