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Virosart® Media

First virus retentive filter for cell culture media.

Protect your cell culture media from virus contaminations with the 20 nm high flux PES Virosart® Media. The filter retains ≥ 4 LRV for small non-enveloped viruses like MVM or Vesivirus and ≥ 6 LRV for large enveloped viruses.

   

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Products (5)

Virosart® Media 1.0 m² - Non-sterile Delivery
Filtration Area
1.0 m² | 10.8 ft²
Integrity Tested
Yes
Delivery Condition
Non sterile - Gamma irradiatable
Virosart®Media 0.3 m² - Non-sterile Delivery
Filtration Area
0.3 m² | 3.2 ft²
Integrity Tested
Yes
Delivery Condition
Non sterile - Gamma irradiatable
Virosart® Media Lab Module 5.0 cm²
Virosart® Media Lab Module 5.0 cm²
Item no.: 3V2--28-BVGML--V
Filtration Area
5 cm²
Integrity Tested
No
Delivery Condition
Sterile - Gamma irradiated
Virosart® Media Lab Module 5.0 cm² - Integrity Tested
Filtration Area
5 cm²
Integrity Tested
Yes
Delivery Condition
Sterile - Gamma irradiated
Virosart® Media 0.3 m² - Sterile Delivery
Filtration Area
0.3 m² | 3.2 ft²
Integrity Tested
Yes
Delivery Condition
Sterile - Gamma irradiated
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Application:

  • Target molecule: The main application for Virosart® Media is virus retentive filtration of chemically defined cell culture media.
  • Virus clearance: Virosart® Media targets the removal of small non-enveloped adventitious viruses (20 nm) e.g. MVM or vesivirus from chemically defined cell culture media.
  • Positioning: Virosart® Media is used after the media preparation step itself before transferring the media into the bioreactor. This can be operated either as in-line filtration (e.g. perfusion) or batch filtration. Performance of the Virosart® Media is independent of the use of powder or liquid media but could be strongly impacted by the media itself. Virosart® Media is optimized for chemically defined media. Protein transmission for mAbs and recombinant proteins is not given for this filter.

Product benefits:

  • Robust virus clearance: Virosart® Media provides high virus safety to the bioreactor as it is qualified for ≥ 4 LRV (Log10 reduction value) of small non-enveloped viruses (e.g. MVM) and ≥ 6 LRV for large enveloped viruses.
  • Short processing times: Based on the optimized Polyethersulfone membrane, Virosart® Media provides highest flow rates and excellent capacity for cell culture media (e.g. ≥ 1000 L/m2 in 4 h).
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up with low footprint requirements. 
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® HF are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual module is tested for integrity and for water flow rate during manufacturing
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins
  • USP Plastic Class Test VI

Application Note

Retention Characteristics of Virosart® Media When Filtering Chemically Defined Cell Culture Media
en 831.2 kB
Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 686.5 kB
Evaluation of Impact on Cell Growth using Chemically defined Cell Culture Media filtered through the Virosart® Media Filter
en 1.0 MB
Evaluating the Filterability of Chemically Defined Cell Culture Media With the Virosart® Media Filter
en 1.1 MB
Evaluating Lot-to-Lot Performance Consistency of Chemically Defined Cell Culture Media During Filtration With the Virosart® Media Filter
en 1.4 MB
Evaluating the Robustness of Virus Clearance Under Challenging Filtration Conditions Using the Virosart® Media Filter
en 525.7 kB
Influence of Cell Culture Media Components on the Filtration Characteristics of Virosart® Media
en 716.7 kB

Datasheet

Virosart® Media - Upstream Virus Retentive Filter
en 932.7 kB
Virus Filter Transfer Units (Gamma)
en 691.8 kB

Flyer

Virosart® Virus Filters - Reliable Retention Under All Circumstances
en 2.8 MB

Poster

Case Study: Virus Risk Mitigation in Cell Culture Media
en 1.0 MB

User Manual

Directions for Use - Virosart® Media Lab Module
en 427.9 kB
Directions for Use - Virosart® Media Mid-Scale Modules
en 415.4 kB
Directions for Use - Virosart ® Media Process Modules
en 401.1 kB

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