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Virosart® HF

New high speed virus filtration.

The high flux PES based virus filter for robust and efficient removal of small non-enveloped and large enveloped viruses in biopharmaceutical applications.

   

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Products (12)

Virosart® HF Mid-Scale Module 0.2 m² - Sterile Delivery
Brand
Virosart® HF
Filtration Area
0.2 m²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HF Mid-Scale Module 200 cm² - Non-sterile Delivery
Brand
Virosart® HF
Filtration Area
200 cm²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HF Mid-Scale Module 0.2 m² - Non-sterile Delivery
Brand
Virosart® HF
Filtration Area
0.2 m²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart® HF Mid-Scale Module 200 cm² - Sterile Delivery
Brand
Virosart® HF
Filtration Area
200 cm²
Integrity Tested
Yes
Filter Type
Virus Filters
Virosart®HF Process Module 2.4 m² - non-sterile delivery
Brand
Virosart® HF
Filtration Area
2.4 m²
Integrity Tested
Yes
Filter Type
Virus Filters

Application:

  • Virus clearance: Virosart® HF targets the removal of both small non-enveloped viruses (20 nm) e.g. PPV, MVM and larger enveloped viruses (> 50 nm) e.g. MuLV from biopharmaceutical feed streams.
  • Target molecule: The main application for Virosart® HF filters is the virus filtration of monoclonal antibodies (mAbs), antibody fragments (Fab) or small recombinant proteins (< 150 kD).
  • Positioning: Virosart® HF is used towards the end of the purification process of biopharmaceutical products for the virus filtration. At this stage, the purity of the biopharmaceutical product is at its highest and so fouling of the filter by contaminants (DNA, CHOP, aggregates & lipoproteins) will be low.

Product Benefits:

  • Robust virus clearance: Virosart® HF retains ≥ 4 LRV of small non-enveloped viruses (e.g. PPV, MVM) and ≥ 6 LRV of large enveloped viruses (e.g. MuLV). This filter offers highest virus safety over the entire flow decay profile independently of operating pressure.
  • Short processing times: Based on a unique modified PES membrane, Virosart® HF provides highest flow rates and excellent capacity.
  • Smart process transfer: The hollow fiber format supplies highest consistency and scalability from lab to process scale.
  • Cost efficiency: The high packing density of the elements combines extremely low hold up and flushing volumes with low footprint requirements.
  • Ready to use: The sterile delivery secures ease of use as well as fast installation of the filter elements.
  • Ease of use: Virosart® HF are tested for integrity using a water-based diffusion test, e.g. based on the Sartocheck® technology of Sartorius Stedim Biotech

Regulatory Compliance

  • Each individual filter is tested for integrity and for water flux during manufacturing
  • Validated for ≥ 4 LRV removal of small non-enveloped viruses using bacteriophage PP7
  • Designed, developed and manufactured in accordance with an ISO 9001 certified Quality Management System
  • Meet or exceed the requirements for WFI quality standards set by the current USP
  • Non pyrogenic according to USP Bacterial Endotoxins

Application Note

Risk Mitigation for Calcium Chloride Solution as an Additive to Cell Culture Media Using High Flux Virus Filters
en 1.5 MB
Impact of Pressure Release and Multiple Pressure Fluctuations on Virus Retention Performance of Virosart® HF
en 857.0 kB
Application Guide - Virosart® HF: High Speed Virus Filtration for mAbs and Recombinant Proteins
en 1.8 MB

Flyer

Virosart® Virus Filters - Reliable Retention Under All Circumstances
en 2.8 MB

Poster

Concept of a Fully Single-Use Virus Filtration
en 1.0 MB
Case Study: Increasing Virus Filter Throughput by Process Optimization Studies
en 894.1 kB
Case Study: Virus Filters Enabling Reliable Process Development in Antibody Processes
en 322.3 kB

User Manual

Directions for Use - Virosart® HF Lab Modules
en 199.4 kB
Directions for Use - Virosart® HF 3VI--28-… Process Modules - Non Sterile
en 576.7 kB

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