Skip to content Skip to navigation menu

CIMmultus® C4 HLD 4000 mL cGMP (2 μm)

CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns.

Item no.:  934.8136-2

Availability:  On Request


CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.

Without the need for column packing, CIMmultus® Monoliths are ready for use out of the box.

This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules such as large proteins, viruses and virus like particles through their ionic interaction with the monolith. The following information is being provided to ensure proper product care and optimal product performance.

C4 (butyl) high ligand density (HLD) features:

  • Strong cation exchanger
  • Working range, pH 2–13
  • Binds molecules with predominantly positive charge, repels molecules a predominantly negative charge
  • Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
  • High capacity for purification of virus and VLP particles, large proteins
  • Sanitizable with 1 M NaOH


  • Channel Size
    2 µm
  • Column Tube Length
    205 mm
  • Inner Diameter
    255 mm
  • Outer Diameter
    300 mm

General Specifications

  • Flow Rate
    500–4000 mL/min | 15–135 cm/h | 0.15–1 CV/min

Operating Conditions

  • Maximum Operating Pressure
    0.7 MPa | 7 bar | 100 psi
  • Recommended Operating Temperature
    4 °C (39 °F) to 40 °C (104 °F)
  • pH Stability
    Working range 3–13, cleaning in place 1–14

eShop Dynamic Attributes

  • Bed Volume
    4000 mL
  • Chemical Compatibility
  • Connectors
    TC 1 in. (25 mm), 8 mm ID bore
  • Ligand
    C4 HLD (hydrophobic, butyl – high ligand density)
  • Materials of Construction
    Poly(butyl methacrylate -co- ethylene dimethacrylate)
  • Package Type
    Individually Packed
  • Reusable