CIMmultus® C4 HLD 400 mL cGMP Compliant (2 μm)
CIMmultus® is a unique and industry-proven line of pre-packed chromatographic monolithic columns featuring large flow-through channels, designed for working with large biomolecules such as viruses (AAV, adenovirus, lentivirus, influenza, bacteriophages), nucleic acids (mRNA, pDNA), virus-like particles and exosomes. CIMmultus® columns can be used as single-use disposable or multi-use columns.
Item no.: 924.8136-2
Availability: On Request
CIMmultus® Monoliths are reusable chromatography devices for scalable high-resolution purification of complex biological samples. Inside the custom designed housing is a single piece stationary phase with homogeneous channel size and surface chemistry. This stationary phase is designed to simplify method transfer from development into production.
Without the need for column packing, CIMmultus® Monoliths are ready for use out of the box.
This high-performance ion exchange column is primarily intended for fast and efficient purification of biomolecules such as large proteins, viruses and virus like particles through their ionic interaction with the monolith. The following information is being provided to ensure proper product care and optimal product performance.
C4 (butyl) high ligand density (HLD) features:
- Strong cation exchanger
- Working range, pH 2–13
- Binds molecules with predominantly positive charge, repels molecules a predominantly negative charge
- Use for capture, intermediate, or polishing steps in either bind-elute or flow-through mode
- High capacity for purification of virus and VLP particles, large proteins
- Sanitizable with 1 M NaOH
Channel Size2 µm
Column Tube Length75 mm
Inner Diameter65 mm
Outer Diameter105 mm
Flow Rate100–800 mL/min | 30–245 cm/h | 0.25–2 CV/min
Maximum Operating Pressure1.4 MPa | 14 bar | 200 psi
Recommended Operating Temperature4 °C (39 °F) to 40 °C (104 °F)
pH StabilityWorking range 3–13, cleaning in place 1–14
eShop Dynamic Attributes
Bed Volume400 mL
ConnectorsTC 1 in. (25 mm), 8 mm ID bore
Materials of ConstructionPoly(butyl methacrylate -co- ethylene dimethacrylate)
Package TypeIndividually Packed